Protein transport events occurring at the endoplasmic reticulum (ER) of eukaryotic cells and the cytoplasmic membrane of prokaryotic organisms share many similarities. Resident proteins of both membranes span the lipid bilayer once or several times by a-helical stretches and their integration is usually mediated by uncleaved signal-anchor sequences. Proteins that are translocated across either membrane, collectively also termed secretory proteins, harbour cleavable N-terminal signal sequences. Prokaryotic and eukaryotic signal sequences have the same modular structure and are functionally exchangeable. Integration of membrane proteins and translocation of secretory proteins basically occur at the same sites (pores) within each membrane. In both types of membranes, these pores are c- posed of homologous components forming the Sec translocons. Parts of the Sec trans- cons are found populated by ribosomes, the membrane-bound ribosomes. Bacterial m- brane and eukaryotic secretory proteins are targeted to the Sec translocons by the same molecular mechanism involving signal recognition particle (SRP) and its receptor (SRP - ceptor, SR). Structure and assembly of the SRP The functional core of SRP The functional core of this ribonucleoprotein complex consists of the signal sequence binding subunit (SRP54 in eukaryotes and Ffh in prokaryotes) and the SRP RNA molecule (see Fig. 1). This core is conserved in all organisms, with the intriguing exception of chloroplasts, where the SRP lacks the RNA subunit.

Michael Merlino lives a charmed life with a successful career, beautiful wife, and beloved son-until his dear father passes away; then things turn strange. Michael can't seem to shake this weird feeling, but maybe he just misses his dad, his mentor. He ignores the feeling that something is wrong.

One day, he accidentally kills a stray cat-a sad but everyday sort of accident; he doesn't give it much thought. When another cat appears in Michael's life, however, it makes him wonder whether the stray cat really died, and whether cats actually do have nine lives, as the saying goes. But this isn't your normal stray kitty. This cat is out for revenge. Its spirit wants something from Michael, but what?

When a man has everything to lose, however, it's much easier to make it happen-especially when that man is up against what appears to be a supernatural enemy. As Michael begins to face his own demons via a demon cat that won't die, his work begins to slide. His life at home gets more difficult, even with his wife there to support him. Then, there was that note his father left that told Michael to "drive it." What did the note mean? Could it possibly have been a warning? The mystery must be solved, as the reincarnated cat keeps getting bigger and meaner, threatening not just Michael's life, but his soul in the bargain.

Rich with doctrinal exactitude and a moving beauty of expression, the prayers and hymns of St. Thomas Aquinas have long been considered to be among the Church's greatest treasures. Now you can bring these treasures into your own prayer life with this first complete English collection of these stirring prayers.

This handy and beautiful leatherette volume brings you all of St. Thomas's known prayers and hymns in their Latin originals, along with new English translations. These translations render the originals with superb precision and a soul-fortifying eloquence that rivals St. Thomas's own masterly use of Latin. A number of these prayers have never before been translated into English.

A hallmark of much of the research on children's thinking in the 1970s had been the focus on explicit content domains. Much of this research had been represented by an eclectic collection of studies sampled from a variety of disciplines and content areas. However, in the few years before this publication, research in several content domains has begun to coalesce into a coherent body of knowledge. Originally published in 1982, the chapters in this work represent one of the first attempts to bring together the perspectives of a variety of different researchers investigating a specific, well defined content domain. This book presents theoretical views and research findings of a group of international scholars who are investigating the early acquisition of addition and subtraction skills by young children. Together, the contributors bring a blend of psychology, educational psychology, and mathematics education to this topic. Fields of interest such as information processing, artificial intelligence, early childhood, and classroom teaching and learning are included in this blend.

This easy-to-read guide provides a concise introduction to the engineering background of modern communication systems, from mobile phones to data compression and storage. Background mathematics and specific engineering techniques are kept to a minimum so that only a basic knowledge of high-school mathematics is needed to understand the material covered. The authors begin with many practical applications in coding, including the repetition code, the Hamming code and the Huffman code. They then explain the corresponding information theory, from entropy and mutual information to channel capacity and the information transmission theorem. Finally, they provide insights into the connections between coding theory and other fields. Many worked examples are given throughout the book, using practical applications to illustrate theoretical definitions. Exercises are also included, enabling readers to double-check what they have learned and gain glimpses into more advanced topics, making this perfect for anyone who needs a quick introduction to the subject.

This easy-to-read guide provides a concise introduction to the engineering background of modern communication systems, from mobile phones to data compression and storage. Background mathematics and specific engineering techniques are kept to a minimum so that only a basic knowledge of high-school mathematics is needed to understand the material covered. The authors begin with many practical applications in coding, including the repetition code, the Hamming code and the Huffman code. They then explain the corresponding information theory, from entropy and mutual information to channel capacity and the information transmission theorem. Finally, they provide insights into the connections between coding theory and other fields. Many worked examples are given throughout the book, using practical applications to illustrate theoretical definitions. Exercises are also included, enabling readers to double-check what they have learned and gain glimpses into more advanced topics, making this perfect for anyone who needs a quick introduction to the subject.

Protein transport events occurring at the endoplasmic reticulum (ER) of eukaryotic cells and the cytoplasmic membrane of prokaryotic organisms share many similarities. Resident proteins of both membranes span the lipid bilayer once or several times by a-helical stretches and their integration is usually mediated by uncleaved signal-anchor sequences. Proteins that are translocated across either membrane, collectively also termed secretory proteins, harbour cleavable N-terminal signal sequences. Prokaryotic and eukaryotic signal sequences have the same modular structure and are functionally exchangeable. Integration of membrane proteins and translocation of secretory proteins basically occur at the same sites (pores) within each membrane. In both types of membranes, these pores are c- posed of homologous components forming the Sec translocons. Parts of the Sec trans- cons are found populated by ribosomes, the membrane-bound ribosomes. Bacterial m- brane and eukaryotic secretory proteins are targeted to the Sec translocons by the same molecular mechanism involving signal recognition particle (SRP) and its receptor (SRP - ceptor, SR). Structure and assembly of the SRP The functional core of SRP The functional core of this ribonucleoprotein complex consists of the signal sequence binding subunit (SRP54 in eukaryotes and Ffh in prokaryotes) and the SRP RNA molecule (see Fig. 1). This core is conserved in all organisms, with the intriguing exception of chloroplasts, where the SRP lacks the RNA subunit.

Die jahrlich erscheinende Reihe bietet eine praxisbezogene Fort- und Weiterbildung speziell fur den niedergelassenen HNO-Arzt und den Klinikassistenten. Die Themen werden so gewahlt, dass in regelmassigem Turnus alle fur die HNO-Praxis wichtigen Bereiche je nach Aktualitat abgehandelt werden. Der HNO-Arzt kann sich mit dieser Reihe eine komprimierte und standig aktuelle Bibliothek der praktischen Hals-Nasen-Ohren-Heilkunde aufbauen, die ihm modernes Fachwissen und das notige "know-how" vermittelt. Die entzundlichen Komplikationen der Otitis media haben im Antibiotikazeitalter einen Gestaltwandel erfahren. Fehldiagnosen vermeiden zu helfen ist das Ziel des ersten Beitrages. Von den Verletzungen im Gesichtsbereich sind die lateralen Frakturen (Jochbein, Jochbogen, blow out) ebenso haufig wie therapeutisch denkbar. Unterschiedliche Gesichtspunkte bei der operativen Versorgung mussen berucksichtigt bzw. koordiniert werden. Die Tonsillitiden sowie die Crux chronische Pharyngitis mit deren Differentialdiagnose gehoren zur taglichen Praxis. Inwieweit spielt die chronische Laryngitis eine Rolle bei der Entstehung des Larynxkarzinoms, und wie behandelt man Prakanzerosen im Kehlkopf? Fragen, die immer wieder diskutiert werden. Wie versorgt man Narben im Gesicht? Dieses Problem stellt sich auch jedem niedergelassenen Arzt. Der Beitrag informiert uber die vielfaltigen Moglichkeiten. Die fundierte Darstellung des Problems Barotraumen wird dem Leser ebenso empfohlen wie die systematische und praxisorientierte Beschreibung der Auswirkungen funktioneller Storungen der Halswirbelsaule mit ihren HNO-Symptomen.

Michael Merlino lives a charmed life with a successful career, beautiful wife, and beloved son-until his dear father passes away; then things turn strange. Michael can't seem to shake this weird feeling, but maybe he just misses his dad, his mentor. He ignores the feeling that something is wrong.

One day, he accidentally kills a stray cat-a sad but everyday sort of accident; he doesn't give it much thought. When another cat appears in Michael's life, however, it makes him wonder whether the stray cat really died, and whether cats actually do have nine lives, as the saying goes. But this isn't your normal stray kitty. This cat is out for revenge. Its spirit wants something from Michael, but what?

When a man has everything to lose, however, it's much easier to make it happen-especially when that man is up against what appears to be a supernatural enemy. As Michael begins to face his own demons via a demon cat that won't die, his work begins to slide. His life at home gets more difficult, even with his wife there to support him. Then, there was that note his father left that told Michael to "drive it." What did the note mean? Could it possibly have been a warning? The mystery must be solved, as the reincarnated cat keeps getting bigger and meaner, threatening not just Michael's life, but his soul in the bargain.