This book reprints Human Guinea Pigs, by Kenneth Mellanby, a seminal work in the history of medical ethics and human subject research that has been nearly unavailable for over 40 years. Detailing the use of World War II conscientious objectors who volunteered for experimentation on scabies transmission, Mellanby's book offers insight into one approach to human subject experimentation before the development of ethical oversight regulations. His work was initially published prior to the articulation of the Nuremberg Code, which makes his subsequent position as a reporter for the British Medical Journal at the Nuremberg Trials very interesting, particularly given his sometimes controversial opinions on Nazi medical experimentation. This book reprints the second edition together with commentary essays that situate Mellanby's ethical approach in historical context and relative to contemporary approaches. This volume is of particular interest to scholars of the history of human subject research.

This volume brings together a set of critical essays on the thought of Professor Doctor H. Tristram Engelhardt Junior, Co-Founding Editor of the Philosophy and Medicine book series. Amongst the founders of bioethics, Professor Engelhardt, Jr. looms large. Many of his books and articles have appeared in multiple languages, including Italian, Romanian, Portuguese, Spanish, and Chinese. The essays in this book focus critically on a wide swath of his work, in the process elucidating, critiquing, and/or commending the rigor and reach of his thought. This volume compasses analyses of many different aspects of Engelhardt's work, including social and political philosophy, biopolitics, the philosophy of medicine, and bioethics. It brings together internationally known scholars to assess key elements of Engelhardt's work.

These cutting-edge international essays challenge dominant narratives of queer youth predicated on oppression and victimization. As school systems address the emergence of Gay-Straight Alliances and calls to provide equal educational access, researchers, educators and youth workers are paying increasing attention to sexuality, gender and schooling. Yet present discourses are limited to liberal understandings of tolerance, safety, and equity that are defined by a separation of "queer" and "normal." This text documents and offers radical interpretations of the creativity of queer youth in challenging existing practices. Interdisciplinary analyses offer multiple vantage points for reconceptualizing adolescent sexual subjectivities and institutional and cultural practices.

Monitoring of Cerebral and Spinal Haemodynamics During Neurosurgery is a comprehensive description of subdural monitoring of intracranial pressure (ICP) during neurosurgery. It offers thorough analysis of a comprehensive database consisting of measurements of ICP, cerebral perfusion pressure and other relevant physiological data from more than 1,800 patients subjected to intracranial surgery at Aarhus University Hospital. Features of anaesthesia, both inhalation and total intravenous, are discussed, and measures to reduce ICP are described. A majority of the patients had supratentorial tumours, but the database also includes patients with infratentorial tumours and patients with no intracranial space-occupying lesions. A chapter is reserved for discussion of the special features of children with cerebral tumours.

After theory and the new historicism, what might a self-conscious turn to formal analysis in Renaissance literary studies look like today? The essays address this question from a variety of critical perspectives, embodying a renewed engagement with questions of form.

This practical book serves as a comprehensive guide to quantitative portfolio optimization, asset allocation, and risk management. Providing an accessible yet rigorous approach to investment management, it gradually introduces ever more advanced quantitative tools for these areas. Using extensive examples, this book guides the reader from basic return and risk analysis, all the way through to portfolio optimization and risk characterization, and finally on to fully fledged quantitative asset allocation and risk management. It employs such tools as enhanced modern portfolio theory using Monte Carlo simulation and advanced return distribution analysis, analysis of marginal contributions to absolute and active portfolio risk, Value-at-Risk and Extreme Value Theory.

This volume brings together a set of critical essays on the thought of Professor Doctor H. Tristram Engelhardt Junior, Co-Founding Editor of the Philosophy and Medicine book series. Amongst the founders of bioethics, Professor Engelhardt, Jr. looms large. Many of his books and articles have appeared in multiple languages, including Italian, Romanian, Portuguese, Spanish, and Chinese. The essays in this book focus critically on a wide swath of his work, in the process elucidating, critiquing, and/or commending the rigor and reach of his thought. This volume compasses analyses of many different aspects of Engelhardt's work, including social and political philosophy, biopolitics, the philosophy of medicine, and bioethics. It brings together internationally known scholars to assess key elements of Engelhardt's work.

Monitoring of Cerebral and Spinal Haemodynamics During Neurosurgery is a comprehensive description of subdural monitoring of intracranial pressure (ICP) during neurosurgery. It offers thorough analysis of a comprehensive database consisting of measurements of ICP, cerebral perfusion pressure and other relevant physiological data from more than 1,800 patients subjected to intracranial surgery at Aarhus University Hospital. Features of anaesthesia, both inhalation and total intravenous, are discussed, and measures to reduce ICP are described. A majority of the patients had supratentorial tumours, but the database also includes patients with infratentorial tumours and patients with no intracranial space-occupying lesions. A chapter is reserved for discussion of the special features of children with cerebral tumours.

These cutting-edge international essays challenge dominant narratives of queer youth predicated on oppression and victimization. As school systems address the emergence of Gay-Straight Alliances and calls to provide equal educational access, researchers, educators and youth workers are paying increasing attention to sexuality, gender and schooling. Yet present discourses are limited to liberal understandings of tolerance, safety, and equity that are defined by a separation of "queer" and "normal." This text documents and offers radical interpretations of the creativity of queer youth in challenging existing practices. Interdisciplinary analyses offer multiple vantage points for reconceptualizing adolescent sexual subjectivities and institutional and cultural practices.

After theory and the new historicism, what might a self-conscious turn to formal analysis in Renaissance literary studies look like today? The essays address this question from a variety of critical perspectives, embodying a renewed engagement with questions of form.

Targeted towards institutional asset managers in general and chief investment officers, portfolio managers and risk managers in particular, this practical book serves as a comprehensive guide to quantitative portfolio optimization, asset allocation and risk management. Providing an accessible yet rigorous approach to investment management, it gradually introduces ever more advanced quantitative tools for these areas. Using extensive examples, this book guides the reader from basic return and risk analysis, all the way through to portfolio optimization and risk characterization, and finally on to fully fledged quantitative asset allocation and risk management. It employs such tools as enhanced modern portfolio theory using Monte Carlo simulation and advanced return distribution analysis, analysis of marginal contributions to absolute and active portfolio risk, Value-at-Risk and Extreme Value Theory. All this is performed within the same conceptual, theoretical and empirical framework, providing a self-contained, comprehensive reading experience with a strongly practical aim.

For the past four or five years much of my thinking has centered up on the relationship of symbolic forms to philosophic imagination, and interpretation. As one whose own philosophic speculations began at. the end of a cultural epoch under methodologies dominated either by neo-Kantianism or schools of logical empiricism the symbol as a prod uct of a cultural imagination has been diminished; it has been neces sary for those who wanted to preserve the symbol to find appropriate philosophical methodologies to do so. In the following chapters we shall attempt to show, through a consideration of a series of recent interpretations of the symbol, as well as through constructive argu ment, that the symbol ought to be considered as a linguistic form in the sense that it constitutes a special language with its own rubrics and properties. There are two special considerations to be taken ac count of in this argument; first, the definition of the symbol, and sec ond, the interpretation of the symbol. Although we shall refrain from defining the symbol explicitly at this point let it suffice to state that our definition of the symbol is more aesthetic than logical (in the technical sense of formal logic), more cultural than individual, more imaginative than scientific. The symbol in our view is somewhere at the center of culture, the well-spring which testifies to the human imagination in its poetic, . psychic, religious, social and political forms."

This book will attempt to achieve a constructive and positive correla tion between mythic-symbolic language and philosophical anthropolo gy. It is intended as a reflection on the philosophical accomplishment of Paul Ricoeur. The term mythic-symbolic language in this context means the language of the multivalent symbol given in the myth with its psychological and poetic counterparts. The term symbol is not con ceived as an abstract sign as it is used in symbolic logic, but rather as a concrete phenomenon - religious, psychological, and poetic. The task inherent in this correlation is monumental when one considers the dual dilemma of problematic and possibility which is at its heart. The prob lematic arises out of the apparent difficulty presented by the so-called challenge of modernity which seems to require the elimination of my thic-symbolic language as an intelligible mode of communication. Mythic-symbolic language is sometimes eliminated because in a world molded by abstract conceptualizations conceptUalizations of science, such a language is thought to be unintelligible. The claim is that its "primitive" explana tions have been transcended by our modernity. Others believe that the problem of mythic-symbolic language is the problem of the myth. If the mythic forms of language could be eliminated, the truth of such language could be preserved through its translation into an intelligible mode of discourse. The problematic is heightened further by the relation of consider ations of language to philosophical anthropology."

This book will attempt to achieve a constructive and positive correla tion between mythic-symbolic language and philosophical anthropolo gy. It is intended as a reflection on the philosophical accomplishment of Paul Ricoeur. The term mythic-symbolic language in this context means the language of the multivalent symbol given in the myth with its psychological and poetic counterparts. The term symbol is not con ceived as an abstract sign as it is used in symbolic logic, but rather as a concrete phenomenon - religious, psychological, and poetic. The task inherent in this correlation is monumental when one considers the dual dilemma of problematic and possibility which is at its heart. The prob lematic arises out of the apparent difficulty presented by the so-called challenge of modernity which seems to require the elimination of my thic-symbolic language as an intelligible mode of communication. Mythic-symbolic language is sometimes eliminated because in a world molded by abstract conceptualizations of science, such a language is thought to be unintelligible. The claim is that its "primitive" explana tions have been transcended by our modernity. Others believe that the problem of mythic-symbolic language is the problem of the myth. If the mythic forms of language could be eliminated, the truth of such language could be preserved through its translation into an intelligible mode of discourse. The problematic is heightened further by the relation of consider ations of language to philosophical anthropology. Any consideration of language involves a related view of the nature of man."

Generals Ulysses S. Grant and Robert E. Lee are two of the most important, and heavily published about, figures in nineteenth-century American history, but despite the enormous amount of published material on the Civil War, including individual biographies of Lee and Grant, there is almost nothing that has been published which looks at these two figures together and which compares them over an extended period of time. This new, fully illustrated book is the first to provide a major re-assessment of their lives, careers and historical impact. This illustrated volume contains over 270 images, pictorial representations of both men, as well as photographs and engravings, and images from popular culture. Leading authors William Rasmussen and Robert Tilton cover both these major figures' lives, from their early education and military training at West Point, through the Civil War and its immediate aftermath, to their retirement.