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From molecule to man: Medical research has indeed taken this
direction, and major improvements of our understanding of the
pathophysiology and epidemiology of disease have been achieved. The
molecular basis of the congenital cardiovascular disorders has been
extended from relatively few congenital malformations into everyday
illnesses such as diabetes mellitus, hyperlipoproteinaemea, and
arterial hypertension. The monogenic and, more difficult, polygenic
basis for a vast majority of cardiovascular disorders are being
defined more precisely from year to year. This book gives an
overview of what has been achieved so far and defines the current
position.
During recent years, it has become evident that ventricular
arrhythmias may arise from myocardial ischemia and that they may be
harbingers of sudden cardiac death. On the other hand, ventricular
arrhythmias may occur without any prognostic significance and
sudden cardiac arrhythmic death may strike without any warning
arrhythmia. The role of ischemia in the genesis of ventricular
arrhythmias and of sudden cardiac death has been observed beyond
doubt. However, the mechanism by which ischemia leads to the
appearance of ventricular arrhythmias and/or sudden cardiac death
has remained rather poorly understood, inspite of rather remarkable
research efforts on the one hand, and the magnitude of the problem
on the other hand. We have therefore set out to assemble scientists
from around the world in order to define the current state of our
knowledge on myocardial ischemia and arrhythmia. Well in line with
the tradition of the Gargellen Conferences, we assembled clinicians
and basic scientists for the 7th Gargellen Conference. This book
presents the proceed- ings of the Symposium in the attempt to
define the current status of our understand- ing of this
significant problem. The Symposium was organized by the Society for
Cooperation in Medicine and Science (SCMS) and was generously
sponsored by Astra Chemicals, Wedel; Bayer AG, Leverkusen;
Boehringer-Mannheim; CPI-Lilly, Giessen; Janssen GmbH, Neuss;
Minden Pharma, Minden; Rahm Pharma, Weiter- stadt; Schering AG,
Berlin, and Siemens AG, Erlangen.
From molecule to man: Medical research has indeed taken this
direction, and major improvements of our understanding of the
pathophysiology and epidemiology of disease have been achieved. The
molecular basis of the congenital cardiovascular disorders has been
extended from relatively few congenital malformations into everyday
illnesses such as diabetes mellitus, hyperlipoproteinaemea, and
arterial hypertension. The monogenic and, more difficult, polygenic
basis for a vast majority of cardiovascular disorders are being
defined more precisely from year to year. This book gives an
overview of what has been achieved so far and defines the current
position.
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