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A remarkable spectrum of novel immunoreceptors sharing related immunoglobulin-like domains and signaling potential has been identified in recent years. These receptors have attracted widespread interest because they resemble the TCR, BCR, and FcR complexes in their ability to serve as activating or inhibitory receptors on the cells that bear them. Moreover, they are well positioned to affect both innate and adaptive immunity. The full range of ligands for these new receptor families is still not known, and understanding of their physiological roles is far from complete. This volume is the first attempt to summarize and highlight all known aspects of immunoglobulin-like receptors, providing a topical overview of the roles and characteristic features of the immunoglobulin-like receptors and related molecules in the immune system. Researchers in immunology, molecular biology, cell biology, clinical medicine, and pharmacology will find this book invaluable.
A remarkable spectrum of novel immunoreceptors sharing related
immunoglobulin-like domains and signaling potential has been
identified in recent years. These receptors have attracted
widespread interest because they resemble the TCR, BCR, and FcR
complexes in their ability to serve as activating or inhibitory
receptors on the cells that bear them. Moreover, they are well
positioned to affect both innate and adaptive immunity. The full
range of ligands for these new receptor families is still not
known, and understanding of their physiological roles is far from
complete. This volume is the first attempt to summarize and
highlight all known aspects of immunoglobulin-like receptors,
providing a topical overview of the roles and characteristic
features of the immunoglobulin-like receptors and related molecules
in the immune system. Researchers in immunology, molecular biology,
cell biology, clinical medicine, and pharmacology will find this
book invaluable.
and how the known vertebrate homologues of these genes are
expressed normally in differentiation and proliferation pathways as
well as abnormal ly in well-defined lymphomagenic and other
oncogenic pathways. What emerged from this meeting are a better
understanding of the evolution of these gene systems themselves and
an elucidation of simpler systems open to more rapid genetic and
molecular genetic analysis to reveal the normal functions of these
genes and their gene products. Thus we sought new answers to
several old questions concerning differenti ation, proliferation,
and neoplastic transformation. We gathered together in an unusual
format - that of the unique Dahlem Workshops - not just to
reiterate data which has recently emerged but to think about how
these findings might lead to new approaches for the understanding
and therapy of the leukemias and lymphomas. We deliberately chose
experts from several different disciplines, ranging from the
clinicians who diag nose, describe, and treat these maladies, to
the molecular geneticists trying to reduce the analysis of the
problem to its simplest variables in the simplest systems
possible."
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Immune Deficiency (Paperback)
M.D. Cooper, A R Lawton, P.A. Miescher, H J Mueller-Eberhard
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R2,768
Discovery Miles 27 680
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Ships in 10 - 15 working days
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The subject of immune deficiency has become of special importance
for two reasons. First, conditions with well defined defects in the
immune system could be analyzed as "experiments of nature" in terms
of finding out the accurate biological relevance of the defective
link in the immune system. Secondly, the recognition of immune
deficiency states has become important in order to provide the
patients with the treatment necessary to remedy these defects. With
regard to immune deficiency states in patients, these have been
instrumental as "experiments of nature" in the revelation by Drs.
Good and Cooper and their associates of the two-component structure
of the immune system, a discovery which can be consi dered as a
major breakthrough in the history of immunopathology. Today's
research allows us to go far beyond this basic two component
structure with the assessment of disorders affecting either cell to
cell interactions or regarding subsets of lymphocyte populations.
Furthermore, the association of immune deficiency with distinct
enzymatic defects of purine metabolism is opening the door to the
molecular level of immune deficiency. Dr. Cooper and Dr. Lawton
have succeeded in obtaining the collaboration of the leaders in the
field of immune deficiency. In view of the importance of their
contributions in scientific and clinical terms, we decided to
prepare a book version of the two issues of Seminars in
Immunopathology devoted to this subject."
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