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All organisms adapt, or at least try to adapt, to informa- tion or
signals arising from their surrounding environment. This can affect
the behaviour of the entire organism or the functioning of discrete
organs or areas within an organism, depending upon its degree of
complexity. This workshop was set up with the aim of encouraging
discussions and collaboration between investiga- tors studying a
wide spectrum of signal transduction/sensing events occurring at
the cell surface in systems where the sig- nalling mechanisms
became attenuated or desensitized after their initial
stimulation/activation. To this end a wide range of sys- tems were
dealt with ranging from simple organisms to higher eUkaryotes.
Desensitization has been of much interest for some time. Recently,
however, a number of novel mechanisms have been elucidated and, in
order to capture the present excitement in this field, the
participants have been encouraged to produce articles which would
present an overview of their field and research effort which, we
hope, will be useful to the int- ested non-speciaJist and
specialist alike. A brief transcript or the ensuing discussions has
also been included ror clarifi- cation and to highlight both points
of comparison between sys- tems and of particular interest.
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