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It is the great glory as it is also the great threat of science
that everything which is in principle possible can be done if the
intention to do it is sufficiently resolute. Peter Medawar, "The
Threat and the Glory" An international symposium on "Cell Signal
Transduction, Second Messengers, and Protein Phosphorylation in
Health and Disease" was held at EI Escorial (Spain) from July 5-9,
1993 as a summer course of the Complutense University in Madrid.
The lectures were delivered by renowned scientists from Europe,
America, and Asia and attended by a large number of young
scientists and graduate students from many countries. During
evolution multicellular organisms have developed the most
sophisticated and heterogeneous signals to maintain in harmony
their multiple functions. The latest and most controversial aspects
and developments in signal transduction were the main focus of this
course. The communication among participants was extremely fluid,
alive, and warm. This allowed the understanding of the key steps in
cellular communication, from their original and historical sources
to the main present hypothesis in the borderline of the latest
scientific discoveries in this field. Without any doubt, the
special atmosphere of the place, the monuments and the old granite
stones, the "patio" with the fountain and the rose garden were
responsible for the cordial meeting. This book comprises the
manuscripts of the participants and we hope it will contribute to
our knowledge of cellular signal transduction and be of value to a
wider scientific community.
Cell Signal Transduction, Second Messengers and Protein
Phosphorylation in Health and Disease (A.M. Municio). Tyrosine
Phosphatases in Cell Cycle and Transformation (E.H. Fischer).
Hydrolysis of Phospholipids and Activation of Protein Kinase C for
Intracellular Signalling (S.I. Nakamura et al.). Induction of
Nitric Oxide Synthase after Protein Kinase C Activation by Phorbol
Esters (S. Hortelano et al.). Metabotropic Glutamate Receptors and
the Activation of Protein Kinase C in the Control of Glutamate
Release (J. SanchezPrieto et al.). Marcks, a Major In Vivo
Substrate of Protein Kinase C. Purification, Interaction with Model
Membrane, and Demyristoylation (S. Manenti et al.). Biochemical and
Immunological Characterization of Protein Kinase C Isozymes in Rat
Kidney Proximal Tubule: Effect of Angiotensin II (J. Poggioli et
al.). Phospholipid Degradation, Second Messengers and Activation of
Cell Signaling Genes (N.G. Bazan, G. Allan). Plateletactivating
Factor and Calcium Signaling: Its Implication in Cellular Responses
(M. Koltai et al.). NMDA Receptorstimulated Release of Arachidonic
Acid: Mechanisms for the Bazan Effect (L.A. Horrocks, A.A.
Farooqui). 12 additional articles. Index.
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