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Each volume of "Advances in Pharmacology" provides a collection of
reviews on timely topics. Volume 31 deals with the mechanisms of
anesthetic actions under normal conditions as well as
pathophysiologic states.;It updates anaesthesiologists and basic
scientists on new aspects of anaesthesia and cardiovascular disease
as it pertains not only to the mechanisms of anesthetic action in
the normal muscle, but also in the presence of a variety of
conditions and diseases such as cardiac ischemia, vascular
disorders and cerebral injury.;The book gives the basic cardiac
effects of anaesthetic along with information on the normal and
ischemic processes controlling or affecting cardiac function, and
contains the most recent experimental observations and hypotheses
with emphasis on cardiovascular effects of anaesthetics and the
mechanisms that may be involved in normal and pathophysiological
states. It discusses the effects of anaethesia on reflex regulation
along with the major circulatory effects of chronic hypertension,
and presents a wide variety of the latest methodologies, from human
studies to subcellular anaesthetic targets. The text also provides
original presentations and interpretat
Each volume of Advances in Pharmacology provides a rich collection
of reviews on timely topics. Emphasis is placed on the molecular
bases of drug action, both applied and experimental.
Key Features
* This volume includes reviews on some of the hottest topics in
pharmacology, including:
* Multidrug resistance and the "MDR"1 gene in gene therapy
* Regulation of calcium channels in epithelial cells
* Gene therapy and vascular disease
* Potential therapeutic applications for Heparin
* Calcium channel blockers
* Antithrombotic agents
* Regulation of potassium channels in epithelial cells
Advances in Pharmacology provides a rich collection of reviews on
timely topics. Emphasis is placed on the molecular bases of drug
action, both applied and experimental. For easy reference, this
volume provides a cumulative subject index covering Volumes 25-44.
Each volume of Advances in Pharmacology provides a rich collection
of reviews on timely topics. Emphasis is placed on the molecular
bases of drug action, both applied and experimental.
Drug-Drug Interactions is a comprehensive review of the scientific
and regulatory perspectives of drug-drug interactions from the
point-of-view of academia, industry, and government regulatory
agencies. This book is intended for professionals in the
pharmaceutical industry, health care, and governmental regulatory
agencies. Topics of interest include the mechanistic understanding
of drug-drug interactions, the prediction of drug-drug interaction
potential of new drugs, and the avoidance of clinically significant
drug-drug interaction in patients.
Key Features
* Provides useful references on the science of drug-drug
interactions
* Describes in a basic and comprehensive manner drug-drug
interactions from the mechanistic viewpoint
* Contains original data from academic and industrial
laboratories
* Presents an overview of regulatory agency positions
Each volume of Advances in Pharmacology provides a rich collection
of reviews on timely topics. Emphasis is placed on the molecular
bases of drug action, both applied and experimental.
Each volume of Advances in Pharmacology provides a rich collection
of reviews on timely topics. Emphasis is placed on the molecular
bases of drug action, both applied and experimental.
Each volume of Advances in Pharmacology provides a rich collection
of reviews on timely topics. Emphasis is placed on the molecular
basis of drug action, both applied and experimental.
Each volume of Advances in Pharmacology provides a rich collection
of reviews on timely topics. Emphasis is placed on the molecular
basis of drug action, both applied and experimental.
Each volume of Advances in Pharmacology provides a rich collection
of reviews on timely topics. Emphasis is placed on the molecular
basis of drug action, both applied and experimental.
Conjugation reactions have long been associated with the
detoxification of xenobiotics. Recent studies suggest that Phase II
reactions are an important mechanism for the bioactivation of
xenobiotics.
This special volume of Advances in Pharmacology features a
two-color dust jacket.
Key Features
* Summarizes the most recent information on:
* Xenobiotic conjugation
* Drug toxicity, hypersensitivity, and targeting
Chemical carcinogenesis
* Glutathione-, sulfate conjugate-, and glucuranide
conjugate-dependent toxicity
* Bioactivation and bioconversion
Each volume of Advances in Pharmacology provides a rich collection
of reviews on timely topics. Emphasis is placed on the molecular
basis of drug action, both applied and experimental.
This volume is dedicated to the topic of cyclic GMP. Chapters
include discussions on the guanylyl cyclase and phosphodiesterase
isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic
GMP-dependent protein kinases, and various hormones and ligands
that regulate cyclic GMP formation and/or metabolism. Several
chapters also deal with some of the effects of cyclic GMP on other
second messengers such as calcium ion transport and smooth muscle
relaxation. Some clinical studies with cyclic GMP and atrial
natriuretic peptide are also discussed. The last chapter raises
many important questions in the field that remain to be addressed.
Key Features
* Isoforms of guanylyl cyclase and phosphodiesterase isoenzyme
families for cyclic GMP synthesis and hydrolysis
* Cyclic GMP-dependent protein kinase
* Hormones and ligands that regulate GMP formation and/or
metabolism
* Effects of cyclic GMP on other second messengers and some
functions such as smooth muscle relaxation and ion transport
* Clinical studies with cyclic GMP and atrial natriuretic
peptide
* Important questions and experiments for the future
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