Each volume of "Advances in Pharmacology" provides a collection of reviews on timely topics. Volume 31 deals with the mechanisms of anesthetic actions under normal conditions as well as pathophysiologic states.;It updates anaesthesiologists and basic scientists on new aspects of anaesthesia and cardiovascular disease as it pertains not only to the mechanisms of anesthetic action in the normal muscle, but also in the presence of a variety of conditions and diseases such as cardiac ischemia, vascular disorders and cerebral injury.;The book gives the basic cardiac effects of anaesthetic along with information on the normal and ischemic processes controlling or affecting cardiac function, and contains the most recent experimental observations and hypotheses with emphasis on cardiovascular effects of anaesthetics and the mechanisms that may be involved in normal and pathophysiological states. It discusses the effects of anaethesia on reflex regulation along with the major circulatory effects of chronic hypertension, and presents a wide variety of the latest methodologies, from human studies to subcellular anaesthetic targets. The text also provides original presentations and interpretat

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.
Key Features
* This volume includes reviews on some of the hottest topics in pharmacology, including:
* Multidrug resistance and the "MDR"1 gene in gene therapy
* Regulation of calcium channels in epithelial cells
* Gene therapy and vascular disease
* Potential therapeutic applications for Heparin
* Calcium channel blockers
* Antithrombotic agents
* Regulation of potassium channels in epithelial cells

Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. For easy reference, this volume provides a cumulative subject index covering Volumes 25-44.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Drug-Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug-drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug-drug interactions, the prediction of drug-drug interaction potential of new drugs, and the avoidance of clinically significant drug-drug interaction in patients.
Key Features
* Provides useful references on the science of drug-drug interactions
* Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint
* Contains original data from academic and industrial laboratories
* Presents an overview of regulatory agency positions

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.
This special volume of Advances in Pharmacology features a two-color dust jacket.
Key Features
* Summarizes the most recent information on:
* Xenobiotic conjugation
* Drug toxicity, hypersensitivity, and targeting
Chemical carcinogenesis
* Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity
* Bioactivation and bioconversion

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

This volume is dedicated to the topic of cyclic GMP. Chapters include discussions on the guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate cyclic GMP formation and/or metabolism. Several chapters also deal with some of the effects of cyclic GMP on other second messengers such as calcium ion transport and smooth muscle relaxation. Some clinical studies with cyclic GMP and atrial natriuretic peptide are also discussed. The last chapter raises many important questions in the field that remain to be addressed.
Key Features
* Isoforms of guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis
* Cyclic GMP-dependent protein kinase
* Hormones and ligands that regulate GMP formation and/or metabolism
* Effects of cyclic GMP on other second messengers and some functions such as smooth muscle relaxation and ion transport
* Clinical studies with cyclic GMP and atrial natriuretic peptide
* Important questions and experiments for the future