A practical and accessible introduction to the bootstrap method----newly revised and updated

Over the past decade, the application of bootstrap methods to new areas of study has expanded, resulting in theoretical and applied advances across various fields. Bootstrap Methods, Second Edition is a highly approachable guide to the multidisciplinary, real-world uses of bootstrapping and is ideal for readers who have a professional interest in its methods, but are without an advanced background in mathematics.

Updated to reflect current techniques and the most up-to-date work on the topic, the Second Edition features:

The addition of a second, extended bibliography devoted solely to publications from 1999-2007, which is a valuable collection of references on the latest research in the field

A discussion of the new areas of applicability for bootstrap methods, including use in the pharmaceutical industry for estimating individual and population bioequivalence in clinical trials

A revised chapter on when and why bootstrap fails and remedies for overcoming these drawbacks

Added coverage on regression, censored data applications, P-value adjustment, ratio estimators, and missing data

New examples and illustrations as well as extensive historical notes at the end of each chapter

With a strong focus on application, detailed explanations of methodology, and complete coverage of modern developments in the field, Bootstrap Methods, Second Edition is an indispensable reference for applied statisticians, engineers, scientists, clinicians, and other practitioners who regularly use statistical methods in research. It is also suitable as a supplementary text for courses instatistics and resampling methods at the upper-undergraduate and graduate levels.

A fundamental and straightforward guide to using and understanding statistical concepts in medical research Designed specifically for healthcare practitioners who need to understand basic biostatistics but do not have much time to spare, The Essentials of Biostatistics for Physicians, Nurses and Clinicians presents important statistical methods used in today's biomedical research and provides insight on their appropriate application. Rather than provide detailed mathematics for each of these methods, the book emphasizes what healthcare practitioners need to know to interpret and incorporate the latest biomedical research into their practices. The author draws from his own experience developing and teaching biostatistics courses for physicians and nurses, offering a presentation that is non-technical and accessible. The book begins with a basic introduction to the relationship between biostatistics and medical research, asking the question "why study statistics?," while also exploring the significance of statisitcal methods in medical literature and clinical trials research. Subsequent chapters explore key topics, including: * Correlation, regression, and logistic regression * Diagnostics * Estimating means and proportions * Normal distribution and the central limit theorem * Sampling from populations * Contingency tables * Meta-analysis * Nonparametric methods * Survival analysis Throughout the book, statistical methods that are often utilized in biomedical research are outlined, including repeated measures analysis of variance, hazard ratios, contingency tables, log rank tests, bioequivalence, cross-over designs, selection bias, and group sequential methods. Exercise sets at the end of each chapter allow readers to test their comprehension of the presented concepts and techniques. The Essentials of Biostatistics for Physicians, Nurses, and Clinicians is an excellent reference for doctors, nurses, and other practicing clinicians in the fields of medicine, public health, pharmacy, and the life sciences who need to understand and apply statistical methods in their everyday work. It also serves as a suitable supplement for courses on biostatistics at the upper-undergraduate and graduate levels.

A comprehensive introduction to bootstrap methods in the R programming environment Bootstrap methods provide a powerful approach to statistical data analysis, as they have more general applications than standard parametric methods. An Introduction to Bootstrap Methods with Applications to R explores the practicality of this approach and successfully utilizes R to illustrate applications for the bootstrap and other resampling methods. This book provides a modern introduction to bootstrap methods for readers who do not have an extensive background in advanced mathematics. Emphasis throughout is on the use of bootstrap methods as an exploratory tool, including its value in variable selection and other modeling environments. The authors begin with a description of bootstrap methods and its relationship to other resampling methods, along with an overview of the wide variety of applications of the approach. Subsequent chapters offer coverage of improved confidence set estimation, estimation of error rates in discriminant analysis, and applications to a wide variety of hypothesis testing and estimation problems, including pharmaceutical, genomics, and economics. To inform readers on the limitations of the method, the book also exhibits counterexamples to the consistency of bootstrap methods. An introduction to R programming provides the needed preparation to work with the numerous exercises and applications presented throughout the book. A related website houses the book's R subroutines, and an extensive listing of references provides resources for further study. Discussing the topic at a remarkably practical and accessible level, An Introduction to Bootstrap Methods with Applications to R is an excellent book for introductory courses on bootstrap and resampling methods at the upper-undergraduate and graduate levels. It also serves as an insightful reference for practitioners working with data in engineering, medicine, and the social sciences who would like to acquire a basic understanding of bootstrap methods.

A uniquely accessible overview of statistics for the medical industry

Statistics is a vital discipline with growing applications across many industries, especially the ever-evolving field of health care, where it plays an essential part in the design of new medical devices, the implementation and analysis of clinical trials, and various epidemiological studies. In today’s modern age of computing, both statistical methodology and its applications are expanding as rapidly as the technology will allow, resulting in an upsurge of new developments and more effective methodologies.

Introductory Biostatistics for the Health Sciences: Modern Applications Including Bootstrap addresses the need for a book that presents a basic, accurate, and up-to-date overview of statistical methodology as it applies to today’s health care industry. The authors, both professionals in the areas of medical consulting and epidemiological research, provide balanced coverage of the latest developments in the industry, liberally illustrated with real-world examples. Students and professionals will find this text helpful in several important ways:

• Presents motivating applications in light of honest theory
• Incorporates resampling statistics software throughout
• Discusses Outliers by way of detection and treatment
• Covers such recent statistical advances as bootstrapping
• Includes helpful exercises throughout

A lucid writing style and numerous real-world examples add to the book’s appeal and value, and make a complex subject uniquely accessible to a diverse audience including medical personnel, public health trainees, as well as nursing and medical students.