This volume contains 10 chapters. The contributions are from researchers - mousintheirrespective?eldsandthechapterscontainhighqualityreviewson topics related to the chemo-biologicalstudies of several different heterocyclic groups. The ?rst chapter from Saracoglu reviews the functionalization of indoles andthepyrrolesviaMichaeladditions, asthesecompoundshavepotential for their biologicalactivities. InsecondchapterMen endezreviewsthechemistryofthewelwitindolinones. Topcu and Demirkiran, in the third chapter, describe the chemistry and biological studies of lignans from Taxus species, including their biosynthesis andrecent strategiesforthesynthesisoflignans.Lignansareaveryimportant classofmolecules, astheyhaveaverydiversespectrumofbiologicalactivities, such as antitumour, antiviral, hepatoprotective, antioxidant, antiulcer, an- allergen, anti-platelet, and anti-osteoporoticactivities. InnextchapterSuzen ] describestheantioxidantactivitiesofsyntheticindole derivatives and their possible mechanisms of action. Inchapter?veGonz alezetal.presentsacomprehensivereviewonthech- istry and biology of the quinoxaline 1,4-dioxide and phenazine 5,10-dioxide typemolecules.Theyalsodiscussthemodeofaction, structure-activitystudies andother relevant chemical andbiologicalproperties forsuch molecules. Inthechaptersix, Khanbrie?ydiscussestheanti-angiogenicandtelomerase inhibitory activities of quinoline and its analogues. Liuet al., inchapterseven, brie?y reviewssomeaspects ofstudies ofbio- tive marine sponge furanosesterterpenoids from the last 10 years, including their totalsyntheses. Pujol et al. in chapter eight, reviews the chemistry, origin and antiviral activities of naturally occurring sulfated polysaccharides for the prevention and controlof viral infections such as HIV-1 and -2, human cytomegalovirus (HCMV), dengue virus (DENV), respiratory syncytial virus (RSV), and - ?uenza Avirus. InchapternineHamdietal.describesthesynthesisandbiologicalactivities of the heterocyclicand vanillin ether coumarins. In the last chapter, Orhan et al. reviews their recent ?ndings on antiviral and antimicrobial heterocyclic compounds fromTurkish plants. Tromso, Norway 2007 Mahmud Tareq Hassan Khan Contents FunctionalizationofIndoleandPyrroleCores viaMichael-TypeAdditions N.Saracoglu ................................ 1 ChemistryoftheWelwitindolinones J.C.Menendez ............................... 63 LignansFrom TaxusSpecies G.Topcu.O.Demirkiran.......................... 103 AntioxidantActivities ofSyntheticIndoleDerivatives andPossibleActivity Mechanisms S.Suzen................................... 145 Quinoxaline 1,4-DioxideandPhenazine5,10-Dioxide."

This volume contains 10 chapters. The contributions are from researchers - mousintheirrespective?eldsandthechapterscontainhighqualityreviewson topics related to the chemo-biologicalstudies of several different heterocyclic groups. The ?rst chapter from Saracoglu reviews the functionalization of indoles andthepyrrolesviaMichaeladditions, asthesecompoundshavepotential for their biologicalactivities. InsecondchapterMen endezreviewsthechemistryofthewelwitindolinones. Topcu and Demirkiran, in the third chapter, describe the chemistry and biological studies of lignans from Taxus species, including their biosynthesis andrecent strategiesforthesynthesisoflignans.Lignansareaveryimportant classofmolecules, astheyhaveaverydiversespectrumofbiologicalactivities, such as antitumour, antiviral, hepatoprotective, antioxidant, antiulcer, an- allergen, anti-platelet, and anti-osteoporoticactivities. InnextchapterSuzen ] describestheantioxidantactivitiesofsyntheticindole derivatives and their possible mechanisms of action. Inchapter?veGonz alezetal.presentsacomprehensivereviewonthech- istry and biology of the quinoxaline 1,4-dioxide and phenazine 5,10-dioxide typemolecules.Theyalsodiscussthemodeofaction, structure-activitystudies andother relevant chemical andbiologicalproperties forsuch molecules. Inthechaptersix, Khanbrie?ydiscussestheanti-angiogenicandtelomerase inhibitory activities of quinoline and its analogues. Liuet al., inchapterseven, brie?y reviewssomeaspects ofstudies ofbio- tive marine sponge furanosesterterpenoids from the last 10 years, including their totalsyntheses. Pujol et al. in chapter eight, reviews the chemistry, origin and antiviral activities of naturally occurring sulfated polysaccharides for the prevention and controlof viral infections such as HIV-1 and -2, human cytomegalovirus (HCMV), dengue virus (DENV), respiratory syncytial virus (RSV), and - ?uenza Avirus. InchapternineHamdietal.describesthesynthesisandbiologicalactivities of the heterocyclicand vanillin ether coumarins. In the last chapter, Orhan et al. reviews their recent ?ndings on antiviral and antimicrobial heterocyclic compounds fromTurkish plants. Tromso, Norway 2007 Mahmud Tareq Hassan Khan Contents FunctionalizationofIndoleandPyrroleCores viaMichael-TypeAdditions N.Saracoglu ................................ 1 ChemistryoftheWelwitindolinones J.C.Menendez ............................... 63 LignansFrom TaxusSpecies G.Topcu.O.Demirkiran.......................... 103 AntioxidantActivities ofSyntheticIndoleDerivatives andPossibleActivity Mechanisms S.Suzen................................... 145 Quinoxaline 1,4-DioxideandPhenazine5,10-Dioxide."

Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research.
This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and "in silico" drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered.
The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations.
* Explains the effects of plant extracts on gene expression profiling.
* Details medicinal plant research from around the world
* Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.