This book discusses recent brain research and the potentially dangerous dual-use applications of the findings of these research projects. The book is divided into three sections: Part I examines the rise in dual-use concerns within various state's chemical and biological non-proliferation regime's during this century, as well as the rapid technologically driven advances in neuroscience and the associated possible misuse considerations in the same period. Part II reviews the brain research projects in the EU, USA, Japan, China and several other countries with regard to their objectives, achievements and measures to deal with the problem of dual-use. Part III assesses the extent to which the results of this civil neuroscience work, which is intended to be benign, are being, and could be protected against future hostile applications in the development of novel chemical and biological weapons.

Incidents of bioterrorism and biowarfare are likely to recur, leading to increased public concern and government action. The deficiencies of the Biological and Toxin Weapons Convention (BTWC) are in urgent need of attention: the BTWC is the central international agreement to prevent the proliferation of biological warfare programmes.

Uniquely, this book is written by diplomats involved in the decade-long effort (1991-2001) in which State Parties to the BTWC tried to agree a Protocol to the Convention with legally binding measures to strengthen its effectiveness, and academics concerned with the negotiations. Just before negotiations foundered, when the Chairman's proposed text was virtually complete, the problems and proposed solutions were examined thoroughly, leading to this book.

The book is wide-ranging in its review of the history of biological warfare, the reasons why the current biological revolution is of such concern, and the main features of the BTWC itself. The core of the book examines the key elements of the proposed protocol - declarations, visits, challenge-type investigations, and enhanced international cooperation - and the implications for government, industry and biodefence, giving us all a better understanding of what still remains to be done to avert a biowarfare catastrophe.

There is increasing concern over the possible use of biological weapons. If they are used, an attack will manifest as a disease outbreak among humans, animals or plants. It is thus important to be able to distinguish between natural disease outbreaks and the result of such an attack. The bok discusses the scientific and technical means available to investigate this question and then goes on to consider the agents of concern. The book concludes with a look forward to future developments.

The Editors would like to thank the authors of the papers at the Advanced Research Workshops for their excellent presentations at the workshops and the production of their drafts. We are indebted to those who helped in the preparation of this volume. We should particularly like to acknowledge the help of Piers Millett, who compiled the papers, set them into camera-ready format and produced the index and Dr. Simon Whitby who made the final changes to the manuscript. Any remaining errors are, of course, our responsibility. Malcolm R. Dando Cyril Klement Marian Negut Graham S. Pearson IX ACHIEVING SECURITY BENEFITS FROM TECHNICAL COOPERATION UNDER THE BIOLOGICAL AND TOXIN WEAPONS CONVENTION GRAHAM S. PEARSON Visiting Professor of International Security, Department of Peace Studies, University of Bradford, Bradford, West Yorkshire BD7 IDP, UK 1. Background l The Biological and Toxin Weapons Convention which opened for signature in 1972 2 and entered into force in 1975 currently has 144 States Parties and 18 Signatory States Article I of the Convention is all-embracing in its complete prohibition of biological weapons stating that: Each State Party to this Convention undertakes never in any circumstances to develop, produce, stockpile or otherwise acquire or retain: (1) Microbial or other biological agents, or toxins whatever their origin or method of production, of types and in quantities that have no justification for prophylactic, protective or other peaceful purposes; (2) Weapons, equipment or means of delivery designed to use such

In the summer of 1997 some twelve lecturers and sixty students met for ten days in Budapest Hungary in a NATO Advanced Studies Institute (ASI) to consider "New Scientific and Technical Aspects of Verification of the Biological and Toxin Weapons Convention." In many ways the meeting was ahead of its time. The Ad Hoc Group was only then about to move to the discussion of a rolling text of the Protocol to the Biological and Toxin Weapons Convention (BTWC). It had been mandated to negotiate the Protocol by the Special Conference which had considered the work of the VEREX process that had taken place following the 1991 Third Review Conference of the Convention. Now, in late 1999, after much further negotiation of the text of the Protocol we are moving towards the endgame of the negotiations. Nevertheless, the scientific and technical issues discussed in the ASI in Hungary continue to be of direct relevance to the verification of the Convention and will continue to be relevant as the eventual Protocol moves from agreement through a Preparatory Commission stage and into full implementation over the next several years. The papers in this volume are much as they were presented in Budapest both in order of presentation and in content. They were designed by the ASI co-directors, Professor Graham Pearson and Ambassador Tibor Toth (Chairman of the Ad Hoc Group) to provide an integrated overview and in-depth analysis of the issues at stake.

This book discusses recent brain research and the potentially dangerous dual-use applications of the findings of these research projects. The book is divided into three sections: Part I examines the rise in dual-use concerns within various state's chemical and biological non-proliferation regime's during this century, as well as the rapid technologically driven advances in neuroscience and the associated possible misuse considerations in the same period. Part II reviews the brain research projects in the EU, USA, Japan, China and several other countries with regard to their objectives, achievements and measures to deal with the problem of dual-use. Part III assesses the extent to which the results of this civil neuroscience work, which is intended to be benign, are being, and could be protected against future hostile applications in the development of novel chemical and biological weapons.

This book explores how revolutionary developments and convergence of the chemical, life and associated sciences are impacting contemporary toxin and bioregulator research, and examines the risks of such research being misused for malign purposes. Investigating illustrative cases of dual use research of potential concern in China, India, Iran, Russia, Syria and the USA, the authors discuss how states can ensure such research and related activities are not utilised in weapons development. Although toxins and bioregulators are, in theory, covered by both the Biological and Toxin Weapons Convention and Chemical Weapons Convention, this apparent overlap in reality masks a dangerous regulatory gap - with neither Convention implemented effectively to address threats of weaponisation. This book highlights the potentially damaging consequences for international peace and security, and proposes realistic routes for action by states and the scientific community.

In the summer of 1997 some twelve lecturers and sixty students met for ten days in Budapest Hungary in a NATO Advanced Studies Institute (ASI) to consider "New Scientific and Technical Aspects of Verification of the Biological and Toxin Weapons Convention." In many ways the meeting was ahead of its time. The Ad Hoc Group was only then about to move to the discussion of a rolling text of the Protocol to the Biological and Toxin Weapons Convention (BTWC). It had been mandated to negotiate the Protocol by the Special Conference which had considered the work of the VEREX process that had taken place following the 1991 Third Review Conference of the Convention. Now, in late 1999, after much further negotiation of the text of the Protocol we are moving towards the endgame of the negotiations. Nevertheless, the scientific and technical issues discussed in the ASI in Hungary continue to be of direct relevance to the verification of the Convention and will continue to be relevant as the eventual Protocol moves from agreement through a Preparatory Commission stage and into full implementation over the next several years. The papers in this volume are much as they were presented in Budapest both in order of presentation and in content. They were designed by the ASI co-directors, Professor Graham Pearson and Ambassador Tibor Toth (Chairman of the Ad Hoc Group) to provide an integrated overview and in-depth analysis of the issues at stake.

Incidents of bioterrorism and biowarfare are likely to recur, leading to increased public concern and government action. The deficiencies of the Biological and Toxin Weapons Convention (BTWC) are in urgent need of attention: the BTWC is the central international agreement to prevent the proliferation of biological warfare programmes. Uniquely, this book is written by diplomats involved in the decade-long effort (1991-2001) in which State Parties to the BTWC tried to agree a Protocol to the Convention with legally binding measures to strengthen its effectiveness, and academics concerned with the negotiations. Just before negotiations foundered, when the Chairman's proposed text was virtually complete, the problems and proposed solutions were examined thoroughly, leading to this book. The book is wide-ranging in its review of the history of biological warfare, the reasons why the current biological revolution is of such concern, and the main features of the BTWC itself. The core of the book examines the key elements of the proposed protocol - declarations, visits, challenge-type investigations, and enhanced international cooperation - and the implications for government, industry and biodefence, giving us all a better understanding of what still remains to be done to avert a biowarfare catastrophe.

The Editors would like to thank the authors of the papers at the Advanced Research Workshops for their excellent presentations at the workshops and the production of their drafts. We are indebted to those who helped in the preparation of this volume. We should particularly like to acknowledge the help of Piers Millett, who compiled the papers, set them into camera-ready format and produced the index and Dr. Simon Whitby who made the final changes to the manuscript. Any remaining errors are, of course, our responsibility. Malcolm R. Dando Cyril Klement Marian Negut Graham S. Pearson IX ACHIEVING SECURITY BENEFITS FROM TECHNICAL COOPERATION UNDER THE BIOLOGICAL AND TOXIN WEAPONS CONVENTION GRAHAM S. PEARSON Visiting Professor of International Security, Department of Peace Studies, University of Bradford, Bradford, West Yorkshire BD7 IDP, UK 1. Background l The Biological and Toxin Weapons Convention which opened for signature in 1972 2 and entered into force in 1975 currently has 144 States Parties and 18 Signatory States Article I of the Convention is all-embracing in its complete prohibition of biological weapons stating that: Each State Party to this Convention undertakes never in any circumstances to develop, produce, stockpile or otherwise acquire or retain: (1) Microbial or other biological agents, or toxins whatever their origin or method of production, of types and in quantities that have no justification for prophylactic, protective or other peaceful purposes; (2) Weapons, equipment or means of delivery designed to use such

There is increasing concern over the possible use of biological weapons. If they are used, an attack will manifest as a disease outbreak among humans, animals or plants. It is thus important to be able to distinguish between natural disease outbreaks and the result of such an attack. The bok discusses the scientific and technical means available to investigate this question and then goes on to consider the agents of concern. The book concludes with a look forward to future developments.

Biotechnology is vital to counter biological and toxin weapons. Without biotechnology, the detection, identification and diagnoses of, and medical countermeasures to such weapons would be virtually impossible. As biological and toxin agents occur in natural outbreaks of disease or intoxications, there are both civil and military benefit to be had from the use of biotechnology in providing effective countermeasures to such agents. The role of biotechnology in countering biological and toxin weapons is here addressed under seven major headings: The wider political and economic contexts; Enabling technologies for BTW agent detection; The applicability of biotechnological methods for BTW agent detection on the battlefield, in a terrorist incident, and in an inspection environment; Pre-exposure medical countermeasures; Diagnosis and identification; Post-exposure treatment and decontamination; Contribution of biotechnology to strengthening international conventions against BTW agents.