Periodontology has a rich background of research and efficient use of this wealth of research data needs to be integrated in periodontal practice. Evidence-based periodontology aims to facilitate such an approach, accelerating the introduction of best research into patient care. The evidence-based approach strives to strengthen clinical experience through the systematic evaluation of information, which allows the clinician to benefit from the amassed data. One must be cautious about interpreting information primarily derived from clinical experience and intuition or poorly designed studies because it can be misleading and/or harmful.