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Nitric oxide is an endogenously produced gas with a wide range of
biological effects and has been implicated in many physiological
and pathophysiological processes. It is released by many cell types
in various organs but is particularly important in the maintenance
of normal lung function. Nitric oxide in exhaled breath has been
identified as a marker for lung disease in some patients. Thus, it
is appropriate to consider the lung separately for the role and
functioning of nitric oxide. The authors identify key areas in the
history, biochemistry, physiology, pathophysiology, immunology and
clinical applications of nitric oxide in the lung. The contents of
this book will be of particular importance to scientists and
clinicians with an interest in lung disease. Moreover, the authors
encompass state of the art opinions of and rational for the
therapeutic potential of nitric oxide and its inhibitors.
to Nitric Oxide Biology.- 1. Nitric Oxide Synthesis and Actions.-
2. Reactive Oxygen and Reactive Nitrogen Species in the Lung.- Role
of Endogenous Nitric Oxide in the Lung.- 3. Non-Adrenergic
Non-Cholinergic Neurotransmission in the Airways: Role of Nitric
Oxide.- 4. Localisation of Nitric Oxide Synthases in the Lung.- 5.
Role of Nitric Oxide in the Regulation of Pulmonary Vascular Tone.-
6. Nitric Oxide and Bronchial Hyperresponsiveness.- 7.
Bronchodilator Actions of Nitric Oxide and Related Compounds.- 8.
Role of Nitric Oxide in Airway Inflammation.- Therapeutic Potential
of Inhalded Nitric Oxide and Nitric Oxide Synthase Inhibitors in
Lung Disease.- 9. Nitric Oxide in Exhaled Air: Relevance in
Inflammatory Lung Disease.- 10. Luminal Nitric Oxide in the Upper
Airways: Implications for Local and Distal Sites of Action.- 11.
Inhaled Nitric Oxide as a Therapy for Diseases of the Pulmonary
Vasculature.- 12. Combinded Use of Nitric Oxide and Nitric Oxide
Synthase Inhibitors as a Possible Therapeutic Approach.
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