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Single-Molecule Enzymology, Part B, the latest volume in the
Methods in Enzymology series, continues the legacy of this premier
serial with quality chapters authored by leaders in the field. This
volume covers research methods in single-molecule enzymology, and
includes sections on such topics as force-based and hybrid
approaches, fluorescence, high-throughput sm enzymology, and
nanopore and tethered particle motion.
In recent years, a number of groundbreaking structural and
mechanistic studies deepened our understanding of helicase
mechanisms and established new approaches for their analyses. Many
fundamental mechanistic questions ranging from the mechanism of
force generation, mechanochemical coupling to distinct mechanisms
by which the same enzyme translocates on DNA removing obstacles,
unwinds DNA and/or remodels nucleoprotein complexes, however,
remain to be answered. It is even less understood how the helicase
motors are incorporated into a wide range of genome maintenance and
repair machines. The field has reached a stage when the studies of
molecular mechanisms and basic biology of helicases can and shall
be integrated with the studies of development, cancer and
longevity. The objective of this book is to provide the first
systematic overview of structure, function and regulation of DNA
helicases and related molecular motors. By integrating the
knowledge obtained through the diverse technical approaches ranging
from single-molecule biophysics to cellular and molecular
biological studies the editors aim to provide a unified view on how
helicases function in the cell, are regulated in response to
different cellular stresses and are integrated into large
macromolecular assemblies to form a complex and adaptive living
system.
In recent years, a number of groundbreaking structural and
mechanistic studies deepened our understanding of helicase
mechanisms and established new approaches for their analyses. Many
fundamental mechanistic questions ranging from the mechanism of
force generation, mechanochemical coupling to distinct mechanisms
by which the same enzyme translocates on DNA removing obstacles,
unwinds DNA and/or remodels nucleoprotein complexes, however,
remain to be answered. It is even less understood how the helicase
motors are incorporated into a wide range of genome maintenance and
repair machines. The field has reached a stage when the studies of
molecular mechanisms and basic biology of helicases can and shall
be integrated with the studies of development, cancer and
longevity. The objective of this book is to provide the first
systematic overview of structure, function and regulation of DNA
helicases and related molecular motors. By integrating the
knowledge obtained through the diverse technical approaches ranging
from single-molecule biophysics to cellular and molecular
biological studies the editors aim to provide a unified view on how
helicases function in the cell, are regulated in response to
different cellular stresses and are integrated into large
macromolecular assemblies to form a complex and adaptive living
system.
Mechanisms of DNA Recombination and Genome Rearrangements: Methods
to Study Homologous Recombination, Volume 600, the latest release
in the Methods in Enzymology series, continues the legacy of this
premier serial with quality chapters authored by leaders in the
field. Homologous genetic recombination remains the most enigmatic
process in DNA metabolism. The molecular machines of recombination
preserve the integrity of the genetic material in all organisms and
generate genetic diversity in evolution. The same molecular
machines that support genetic integrity by orchestrating accurate
repair of the most deleterious DNA lesions, however, also promote
survival of cancerous cells and emergence of radiation and
chemotherapy resistance. This two-volume set offers a comprehensive
set of cutting edge methods to study various aspects of homologous
recombination and cellular processes that utilize the enzymatic
machinery of recombination The chapters are written by the leading
researches and cover a broad range of topics from the basic
molecular mechanisms of recombinational proteins and enzymes to
emerging cellular techniques and drug discovery efforts.
Mechanisms of DNA Recombination and Genome Rearrangements:
Intersection between Homologous Recombination, DNA Replication and
DNA Repair, Volume 601, the latest release in the Methods in
Enzymology series, continues the legacy of this premier serial with
quality chapters authored by leaders in the field. Homologous
genetic recombination remains the most enigmatic process in DNA
metabolism. The molecular machines of recombination preserve the
integrity of the genetic material in all organisms and generate
genetic diversity in evolution. The same molecular machines that
support genetic integrity by orchestrating accurate repair of the
most deleterious DNA lesions, however, also promote survival of
cancerous cells and emergence of radiation and chemotherapy
resistance. This two-volume set offers a comprehensive set of
cutting edge methods to study various aspects of homologous
recombination and cellular processes that utilize the enzymatic
machinery of recombination. The chapters are written by the leading
researches and cover a broad range of topics from the basic
molecular mechanisms of recombinational proteins and enzymes to
emerging cellular techniques and drug discovery efforts.
Single-Molecule Enzymology, Part A, the latest volume in the
Methods in Enzymology series, continues the legacy of this premier
serial with quality chapters authored by leaders in the field. This
volume covers research methods in single-molecule enzymology, and
includes sections on such topics as force-based and hybrid
approaches, fluorescence, high-throughput sm enzymology, nanopores,
and tethered particle motion.
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