This detailed book describes some of the most recent advances and up-to-date methodologies to detect, quantify, analyze, and elucidate the biological function of different types of RNA modifications. Importantly, the methodologies and tools described herein can be applied to a wide variety of organisms and can be used to address biological and clinical questions. Beginning with a section on bioinformatics tools, the collection continues with sections on detecting RNA modifications using Nanopore direct RNA sequencing, next-generation sequencing approaches, qPCR- and molecular biology-based methods, mass spectrometry- and NMR-based methods, as well as approaches to assess kinetics, determinants, and functions of RNA modifications. Written for the highly successful Methods in Molecular Biology series style, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, RNA Modifications: Methods and Protocols serves as an ideal guide for those working directly in the fields of epitranscriptomics and post-transcriptional gene regulation, as well as for scientists and clinicians interested in bioinformatic tools to study RNA modifications and techniques to dissect their roles in physiology and disease. Chapter 20 is available open access under a CC BY 4.0 license.

Women's careers have been a topic of research and discussion in many disciplines including sociology, business, industrial, organisational and vocational psychology, and career guidance. Despite the introduction of equal employment legislation in many countries, women's patterns of career development continue to reflect structural labour market disadvantage. This unique book brings together expert contributions from academic researchers, as well as representing the voices of older women who participated in an international research investigation. Grounded in multidisciplinary empirical studies, the book provides: * a variety of perspectives on women's careers in the 21st century * an international exploration of the voice of the older woman * an understanding of both the challenges and responses to women as they construct their careers. Offering a comprehensive understanding of women's career development throughout the lifespan, this book will be of key interest to academics and researchers from the fields of education, psychology, management, geography, labour market economics and sociology, as well as career practitioners, managers, trainers, researchers and policy developers.

In Postsocial History: An Introduction, historian Miguel A. Cabrera points to the crisis of modernity as a locus for the collapse of social historical models. Previously established theories of social change and social relations are proving insufficient, calling for the emergence of a new social historical theory. Cabrera finds the answer in language, which, more than being a mere communicative tool, he believes to be capable of playing an active role in the forces of social change. Postsocial History is a lucid and unprecedented account of the need for a new, modern theoretical model. By arguing convincingly for the inclusion of language in that model, Cabrera awakens a revolutionary new approach to historiography. This book will prove indispensable to historians, and to social scientists in general, who are dissatisfied with the old paradigms and seek new ways of addressing the challenges of social research.

In Postsocial History: An Introduction, historian Miguel A. Cabrera points to the crisis of modernity as a locus for the collapse of social historical models. Previously established theories of social change and social relations are proving insufficient, calling for the emergence of a new social historical theory. Cabrera finds the answer in language, which, more than being a mere communicative tool, he believes to be capable of playing an active role in the forces of social change. Postsocial History is a lucid and unprecedented account of the need for a new, modern theoretical model. By arguing convincingly for the inclusion of language in that model, Cabrera awakens a revolutionary new approach to historiography. This book will prove indispensable to historians, and to social scientists in general, who are dissatisfied with the old paradigms and seek new ways of addressing the challenges of social research.

Due to the increasing demand for career guidance in recent years, career counsellors have been challenged to modernise their practice. As a response to the rapidly changing world of work, with more diverse client groups and more complex and challenging issues facing career counsellors, the field has moved strongly towards the greater adoption of constructivist approaches. The 2nd edition of this ground breaking book is a forward-looking guide, giving further insight into the constructivist approach for the 21st century by: providing a theoretical background to constructivism; alerting readers to a range of cultural considerations related to constructivist career counselling; outlining a range of constructivist approaches to career counselling; providing examples of practical applications of the constructivist approaches presented in the book; and assisting career counsellor educators, practitioners and students understand and implement constructivist approaches into their work. With contributions from an internationally recognised panel of authors from ten different countries, Career Counselling: Constructivist Approaches treats career as a holistic concept in which work and personal life are inseparably intertwined, and individuals as experts in their own lives and in actively constructing their careers. Structured into four logical sections, this 2nd edition attests to the ongoing influence of constructivism internationally and the continued development and refinement of constructivist approaches to career counselling. Career Counselling: Constructivist Approaches is essential reading for career counsellor educators, practitioners, researchers and students who want a refreshing insight into constructivist career counselling.

This detailed book describes some of the most recent advances and up-to-date methodologies to detect, quantify, analyze, and elucidate the biological function of different types of RNA modifications. Importantly, the methodologies and tools described herein can be applied to a wide variety of organisms and can be used to address biological and clinical questions. Beginning with a section on bioinformatics tools, the collection continues with sections on detecting RNA modifications using Nanopore direct RNA sequencing, next-generation sequencing approaches, qPCR- and molecular biology-based methods, mass spectrometry- and NMR-based methods, as well as approaches to assess kinetics, determinants, and functions of RNA modifications. Written for the highly successful Methods in Molecular Biology series style, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, RNA Modifications: Methods and Protocols serves as an ideal guide for those working directly in the fields of epitranscriptomics and post-transcriptional gene regulation, as well as for scientists and clinicians interested in bioinformatic tools to study RNA modifications and techniques to dissect their roles in physiology and disease. Chapter 20 is available open access under a CC BY 4.0 license.

In response to the complexities of social change that have become evident in the 21st century, there is a need for innovation in career theory that takes into account new perspectives and the fluctuating contexts of people's lives. Contemporary Theories of Career Development: International Perspectives brings together the contributions of theorists from around the globe whose work represents current, cutting-edge international approaches to career development theory. Emphasizing the new perspectives that are needed for this field to be relevant in a contemporary era, this book considers the cultural applications of theory in a diverse range of populations. Structured in three parts with chapters written by internationally renowned leaders in the field, this collection features a critical examination of the current history of the field; thirteen theory chapters, each enhanced by a case study; and a final chapter that draws the previous chapters together through key themes, broadening the reader's knowledge of theoretical perspectives and their interrelations. Each theory chapter author comments on and critiques his or her own theory, inviting readers to engage with these theories at both a practical and theoretical level through the case studies. Detailed, with reader-friendly descriptions and supplemented by international research, case examples, and discussion questions, Contemporary Theories of Career Development: International Perspectives is the ideal reference work for students studying the topic as well as a stimulus for researchers and practitioners looking to implement the theories in their work.

Due to the increasing demand for career guidance in recent years, career counsellors have been challenged to modernise their practice. As a response to the rapidly changing world of work, with more diverse client groups and more complex and challenging issues facing career counsellors, the field has moved strongly towards the greater adoption of constructivist approaches. The 2nd edition of this ground breaking book is a forward-looking guide, giving further insight into the constructivist approach for the 21st century by: providing a theoretical background to constructivism; alerting readers to a range of cultural considerations related to constructivist career counselling; outlining a range of constructivist approaches to career counselling; providing examples of practical applications of the constructivist approaches presented in the book; and assisting career counsellor educators, practitioners and students understand and implement constructivist approaches into their work. With contributions from an internationally recognised panel of authors from ten different countries, Career Counselling: Constructivist Approaches treats career as a holistic concept in which work and personal life are inseparably intertwined, and individuals as experts in their own lives and in actively constructing their careers. Structured into four logical sections, this 2nd edition attests to the ongoing influence of constructivism internationally and the continued development and refinement of constructivist approaches to career counselling. Career Counselling: Constructivist Approaches is essential reading for career counsellor educators, practitioners, researchers and students who want a refreshing insight into constructivist career counselling.

Women's careers have been a topic of research and discussion in many disciplines including sociology, business, industrial, organisational and vocational psychology, and career guidance. Despite the introduction of equal employment legislation in many countries, women's patterns of career development continue to reflect structural labour market disadvantage. This unique book brings together expert contributions from academic researchers, as well as representing the voices of older women who participated in an international research investigation. Grounded in multidisciplinary empirical studies, the book provides: * a variety of perspectives on women's careers in the 21st century * an international exploration of the voice of the older woman * an understanding of both the challenges and responses to women as they construct their careers. Offering a comprehensive understanding of women's career development throughout the lifespan, this book will be of key interest to academics and researchers from the fields of education, psychology, management, geography, labour market economics and sociology, as well as career practitioners, managers, trainers, researchers and policy developers.

In response to the complexities of social change that have become evident in the 21st century, there is a need for innovation in career theory that takes into account new perspectives and the fluctuating contexts of people's lives. Contemporary Theories of Career Development: International Perspectives brings together the contributions of theorists from around the globe whose work represents current, cutting-edge international approaches to career development theory. Emphasizing the new perspectives that are needed for this field to be relevant in a contemporary era, this book considers the cultural applications of theory in a diverse range of populations. Structured in three parts with chapters written by internationally renowned leaders in the field, this collection features a critical examination of the current history of the field; thirteen theory chapters, each enhanced by a case study; and a final chapter that draws the previous chapters together through key themes, broadening the reader's knowledge of theoretical perspectives and their interrelations. Each theory chapter author comments on and critiques his or her own theory, inviting readers to engage with these theories at both a practical and theoretical level through the case studies. Detailed, with reader-friendly descriptions and supplemented by international research, case examples, and discussion questions, Contemporary Theories of Career Development: International Perspectives is the ideal reference work for students studying the topic as well as a stimulus for researchers and practitioners looking to implement the theories in their work.

Career Exploration and Development in Childhood presents chapters from leading figures in the field of childhood career exploration and development. The first substantive edited collection of its kind, this book makes an important contribution to our understanding of children's career development. It provides cutting-edge theory, research and practice for understanding and fostering career exploration and development during childhood, across a wide spectrum of international settings. Divided into five sections that reflect the authors' perspectives on critical aspects of children's career development, chapters include relevant research, as well as the practical application of concepts, issues and strategies for career interventions with children. The book includes sequential sections on theory, research, contextual influences, assessment, and the facilitation of career exploration and development. Perspectives from both developed and developing world contexts consider traditional approaches to career education, as well as career development learning in childhood. The collaborations evident in the chapter authorship reflect the significant internationalisation of the field of child career development. The book synthesises key issues and presents innovative recommendations that will not only enhance our understanding of children's career development, but will set the agenda for the future of the field. It will be of key interest to researchers, academics and postgraduate students in the fields of career development, career guidance, education, childhood, child development and counselling.

Career Exploration and Development in Childhood presents chapters from leading figures in the field of childhood career exploration and development. The first substantive edited collection of its kind, this book makes an important contribution to our understanding of children's career development. It provides cutting-edge theory, research and practice for understanding and fostering career exploration and development during childhood, across a wide spectrum of international settings. Divided into five sections that reflect the authors' perspectives on critical aspects of children's career development, chapters include relevant research, as well as the practical application of concepts, issues and strategies for career interventions with children. The book includes sequential sections on theory, research, contextual influences, assessment, and the facilitation of career exploration and development. Perspectives from both developed and developing world contexts consider traditional approaches to career education, as well as career development learning in childhood. The collaborations evident in the chapter authorship reflect the significant internationalisation of the field of child career development. The book synthesises key issues and presents innovative recommendations that will not only enhance our understanding of children's career development, but will set the agenda for the future of the field. It will be of key interest to researchers, academics and postgraduate students in the fields of career development, career guidance, education, childhood, child development and counselling.

The author, counselling psychologist Ann Marie McMahon, introduces a new down-to-earth approach to personal development. The fresh ideas offered in this book cover problems many of us experience in our daily lives. Whether dealing with troublesome relationships, lack of self-confidence, addiction or the blues, one is urged to deal with the issues involved rather than reach for the tissue box. This book takes an innovative and imaginative look at all aspects of life and provides practical advice on how to rejuvenate and re-evaluate our mental and emotional state. The author reminds the reader that there are always options available, and shares some useful techniques for assessing which ones are most helpful. The book is vital for everyone who thinks they are perfect and for those of us who know we are not!

Career development in the 21st century presents many challenges and opportunities to adolescents. They must navigate a complex and rapidly changing world of work influenced by technology, globalisation and fluctuating economic conditions.My System of Career Influences (MSCI) (Adolescent) is a qualitative tool which can be administered in individual counselling sessions or in a group setting. It is ideally suited as a resource for classroom-based career education programs. It consists of a workbook that is completed by young client(s) and the Facilitator's Guide. The Guide contains career decision case studies and suggested learning activities that are particularly useful for practitioners working in school contexts to introduce career concepts and terms. The MSCI workbook is designed so that it can be administered on two separate occasions. The MSCI has applicability across cultures and can accommodate a wide array of career issues. This Facilitator's Guide describes the Systems Theory Framework of career development that provides the theoretical background to the MSCI as well as a step-by-step user guide to conducting the MSCI (Adolescent) process using the MSCI (Adolescent) Workbook (sold separately).With its attention to an holistic and storied approach to career intervention, My System of Career Influences (MSCI) (Adolescent) is an essential resource for all career practitioners working with adolescents.

Career development in the 21st century presents many challenges and opportunities. Throughout your life you will make countless decisions and experience numerous transitions. Each decision may be subject to a range of influences, for example people you know may give you an opinion, you may be attracted to a particular place or a particular salary, or you may simply want a change. No two people will have the same pattern of influences. The My System of Career Influences (MSCI) (Adolescent) is a qualitative career assessment reflection process based on recent developments in theory and practice. It encourages a narrative and story-based approach to your career development. It has been used successfully with adolescents, including school students, in one-on-one career counselling sessions as well as in a group setting. This client booklet is to be used in conjunction with the MSCI (Adult) Facilitators Guide.