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The regulation of gene expression in many biological processes
involves epigenetic mechanisms. In this new volume, 36 chapters
written by experts in the field discuss epigenetic effects from
many perspectives. There are chapters on the basic molecular
mechanisms underpinning epigenetic regulation, discussion of
cellular processes that rely on this kind of regulation, and
surveys of organisms in which it has been most studied. Thus, there
are chapters on histone and DNA methylation, siRNAs and gene
silencing; X-chromosome inactivation, dosage compensation and
imprinting; and discussion of epigenetics in microbes, plants,
insects, and mammals. The last part of the book looks at how
epigenetic mechanisms act in cell division and differentiation, and
how errors in these pathways contribute to cancer and other human
diseases. Also discussed are consequences of epigenetics in
attempts to clone animals. This book is a major resource for those
working in the field, as well as being a suitable text for advanced
undergraduate and graduate courses on gene regulation.
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