This book constitutes the proceedings of the 41st International Conference on Computer Safety, Reliability and Security, SAFECOMP 2022, which took place in Munich, Germany, in September 2022.The 24 full papers included in this volume were carefully reviewed and selected from 93 submissions. SafeComp has contributed to the progress of the state-of-the-art in dependable application of computers in safety-related and safety-critical systems. SafeComp is an annual event covering the state-of-the-art, experience and new trends in the areas of safety, security and reliability of critical computer applications.

This book constitutes the proceedings of the Workshops held in conjunction with SAFECOMP 2022, which took place in Munich, Germany, in September 2022.The 23 full papers included in this volume were carefully reviewed and selected from 27 submissions. * 17th International ERCIM/EWICS/ARTEMIS Workshop on Dependable Smart Embedded Cyber-Physical Systems and Systems-of-Systems (DECSoS 2021) * 3rd International Workshop on Dependable Development-Operation Continuum Methods for Dependable Cyber-Physical System (DepDevOps 2022) * 9th International Workshop on Next Generation of System Assurance Approaches for Critical Systems (SASSUR 2022) * 1st International Workshop on Security and Safety Interaction (SENSEI 2022) * 3rd International Workshop on Underpinnings for Safe Distributed Artificial Intelligence (USDAI 2022) * 5th International Workshop on Artificial Intelligence Safety Engineering (WAISE 2022)