The Frontal Lobes, Volume 163, updates readers on the latest thinking on the structure and function of the human frontal lobe. Sections address methodology, anatomy, physiology and pharmacology, function, development, aging and disorders, and rehabilitation. Patients with focal lesions in the frontal lobes have long been studied to reveal the organization and function of the frontal lobes. Over the last two decades, studies of patients with neurodegenerative diseases and developmental disorders have increased, with new findings discussed in this volume. In addition, the book includes discussions on genetics and molecular biology, optogenetics, high-resolution structural and functional neuroimaging and electrophysiology, and more. Lastly, new knowledge on the biology, structure and function of the frontal lobes, new treatment targets for pharmacology, non-invasive brain stimulation, and cognitive/social remediation are presented. The last section covers new efforts that will hopefully lead to better outcomes in patients with frontal lobe disorders.

Functional imaging has the capability to reveal changes in the pathophysiology of tissues and organ systems, mapping the progression and severity of disease, uptake of drugs, and the recovery of tissues following trauma, disease episodes or surgery. In this authoritative new work, leading specialists in neurology and neuroimaging present an update on the MRI and PET investigation of diseases of the central nervous system. An insightful reference for anyone working in the field, this work discusses how these new technologies can be used to investigate the most important disorders encountered in clinical neurology and psychiatry, ranging from chronic progressive diseases such as Alzheimer's, episodic disruptions of function as seen in epilepsy, and the subtle changes caused by drug dependency and abuse.

This reference text provides an insightful and unified synthesis of cognitive neuroscience and behavioral neurology. The strong clinical emphasis and outstanding illustrations will provide neurologists, psychiatrists, neuropsychologists, and psychologists with a solid foundation to the major neurobehavioral syndromes. With backgrounds in behavioral neurology, functional imaging and cognitive neuroscience, the two authors are in an ideal position to cover the anatomy, genetics, physiology, and cognitive neuroscience underlying these disorders. Their emphasis on therapy makes the book a "must read" for anyone who cares for patients with cognitive and behavioral disorders.

This book contains chapters from experts in the fields of brain imaging, clinical neuroscience, and cognitive neuroscience who have studied the aging brain. Topics covered include technical factors in brain imaging, pathological basis of age-related structural and functional changes, neurochemistry and genetics of brain imaging in aging, and the use of imaging techniques in diagnosis, longitudinal testing, drug development and testing, and presymptomatic detection. The book is intended to be both a detailed review of the current status of brain imaging and aging and to serve as an introduction to the field for those who may be starting investigations using imaging techniques of PET, structural MRI, and functional MRI. It covers basic science approaches such as using fMRI to probe networks, as well as recent developments like amyloid imaging and the use of imaging as a biomarker in clinical trials.

Working memory and perceptual attention are related functions, engaging many similar mechanisms and brain regions. As a consequence, behavioral and neural measures often reveal competition between working memory and attention demands. Yet there remains widespread debate about how working memory operates, and whether it truly shares processes and representations with attention. This Element will examine local-level representational properties to illuminate the storage format of working memory content, as well as systems-level and brain network communication properties to illuminate the attentional processes that control working memory. The Element will integrate both cognitive and neuroscientific accounts, describing shared substrates for working memory and perceptual attention, in a multi-level network architecture that provides robustness to disruptions and allows flexible attentional control in line with goals.

Working memory has been one of the most intensively studied systems in cognitive psychology. It is only relatively recently however that researchers have been able to study the neural processes might underlye working memory, leading to a proliferation of research in this domain.
The Cognitive Neuroscience of Working Memory brings together world class researchers from around the world to summarize our current knowledge of this field, and directions for future research. An historical opening chapter by Alan Baddeley and Graham Hitch sets the context for the subsequent chapters. The scope of the book is exceptionally broad, providing a showcase for leading edge research on all contemporary concepts of working memory, using techniques from experimental psychology, from single cell recording, from neuropsychology, from cognitive neuroimaging and from computational modelling.
The Cognitive Neuroscience of Working Memory will be an important reference text for all those seeking an authoritative and comprehensive synthesis of this field.