Functional imaging has the capability to reveal changes in the pathophysiology of tissues and organ systems, mapping the progression and severity of disease, uptake of drugs, and the recovery of tissues following trauma, disease episodes or surgery. In this authoritative new work, leading specialists in neurology and neuroimaging present an update on the MRI and PET investigation of diseases of the central nervous system. An insightful reference for anyone working in the field, this work discusses how these new technologies can be used to investigate the most important disorders encountered in clinical neurology and psychiatry, ranging from chronic progressive diseases such as Alzheimer's, episodic disruptions of function as seen in epilepsy, and the subtle changes caused by drug dependency and abuse.

The Frontal Lobes, Volume 163, updates readers on the latest thinking on the structure and function of the human frontal lobe. Sections address methodology, anatomy, physiology and pharmacology, function, development, aging and disorders, and rehabilitation. Patients with focal lesions in the frontal lobes have long been studied to reveal the organization and function of the frontal lobes. Over the last two decades, studies of patients with neurodegenerative diseases and developmental disorders have increased, with new findings discussed in this volume. In addition, the book includes discussions on genetics and molecular biology, optogenetics, high-resolution structural and functional neuroimaging and electrophysiology, and more. Lastly, new knowledge on the biology, structure and function of the frontal lobes, new treatment targets for pharmacology, non-invasive brain stimulation, and cognitive/social remediation are presented. The last section covers new efforts that will hopefully lead to better outcomes in patients with frontal lobe disorders.

Working memory and perceptual attention are related functions, engaging many similar mechanisms and brain regions. As a consequence, behavioral and neural measures often reveal competition between working memory and attention demands. Yet there remains widespread debate about how working memory operates, and whether it truly shares processes and representations with attention. This Element will examine local-level representational properties to illuminate the storage format of working memory content, as well as systems-level and brain network communication properties to illuminate the attentional processes that control working memory. The Element will integrate both cognitive and neuroscientific accounts, describing shared substrates for working memory and perceptual attention, in a multi-level network architecture that provides robustness to disruptions and allows flexible attentional control in line with goals.

This reference text provides an insightful and unified synthesis of cognitive neuroscience and behavioral neurology. The strong clinical emphasis and outstanding illustrations will provide neurologists, psychiatrists, neuropsychologists, and psychologists with a solid foundation to the major neurobehavioral syndromes. With backgrounds in behavioral neurology, functional imaging and cognitive neuroscience, the two authors are in an ideal position to cover the anatomy, genetics, physiology, and cognitive neuroscience underlying these disorders. Their emphasis on therapy makes the book a "must read" for anyone who cares for patients with cognitive and behavioral disorders.