This second edition updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson s disease, Alzheimer s disease, and spinal cord injury.
* Incorporates information gained from cutting-edge photomicroscopy techniques
* Includes current information on clinical trials
* Presents chapters on stem cells and other novel treatments for diseases of the CNS

Until recently, scientists believed that the central nervous system (CNS) could not be regenerated. In the 1980s and 1990s, it has become increasingly clear that the adult brain and spinal cord are responsive to signals provided by several classes of molecules. This capacity for regeneration is rarely expressed in the central nervous system in the absence of specific intervention, but can be readily elicited by experimental manipulation. The culmination of these interventions is functional recovery, a phenomenon that has now been demonstrated in animal models of nervous system trauma, stroke, degeneration, and inherited degenerative disease. Based upon preclinical studies, several of these approaches are now undergoing clinical testing. Science has entered a new era in the treatment of disease of the nervous system.;This work focuses on some of the leading current neurological disease models and methods for promoting central nervous system regeneration. In a comprehensive, logical manner, the book unites important basic science advances in neuroscience with novel medical strategies.

Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration. Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.