RAN: AN ATYPICAL GTPASE Mark G. Rush and Peter D'Eustachio New York University School o/Medicine. Department,o/Biochemistry New York NY 10016 ABSTRACT GTPases, proteins that bind and hydrolyze GTP (guanosine triphos- phate) are critical regulators of many metabolic pathways. Although these proteins are enzymes that catalyze the hydrolysis of GTP to GDP + Pi, their primary function is not the hydrolysis of GTP per se, but rather the coupling of this hydrolysis to metabolic regulation. Such coupling is gen- erally achieved through the interaction of the GTP-bound form of the GTPase with proteins known as *effectors. Effectors are often enzymes whose activities are modulated by the GTPase. However, effectors can also be structural proteins involved in assembling intracellular macromo- lecular complexes, such as actin filaments and microtubules, as well as proteins involved in the intracellular transport of proteins and RNAs. In- deed, the subject of this anthology, the small GTPase Ran, may exert most or all of its regulatory functions by interacting with non-enzyme effectors. This property of Ran distinguishes it from other well studied GTPases, and has resulted in the elucidation of novel mechanisms of Ran action that are quite distinct from previously established paradigms of GTPase function. 1. INTRODUCTION The Ras-related nuclear protein Ran is a highly conserved (80% identity among yeasts and humans) member of the Ras superfamily of small GTP binding and hydrolyzing proteins.

"Playing the Violin" is designed as a textbook for music education students in String Pedagogy courses. Elementary and secondary level music teachers are all involved with leading orchestras, and thus have to be conversant with basic techniques on a number of instruments, most notably the violin. Yet few understand the importance of "setup" for establishing proper technique. "Setup" refers to the basic physical elements of violin playing: How to hold the violin and bow; posture and position; movements left and right; and so forth. These are the fundamental components necessary for success. The earlier these concepts are established, the better. Unfortunately, many students reach the university level with bad habits and poor technique, and need to be re-educated about how to perform-and teach-proper violin technique.
While there are other violin pedagogy books on the market, most are very dense with text and give little step-by-step information. They are often aimed at advanced performers, rather than beginners or teachers charged with helping beginning players. "Playing the Violin" takes students and teachers step-by-step through the basics, with an equal emphasis on clear, easy-to-understand photographs as with the text itself. The author assumes no previous knowledge about violin playing. For this reason, the book should appeal not only to violinists and their teachers but to all educators faced with the task of helping string players perform to their maximum potential.
"Playing the Violin" promises to set a new standard for string technique courses. It will appeal to college and university students but also will be useful for independent violin teachers and those learning "ontheir own."

The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.

The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.

RAN: AN ATYPICAL GTPASE Mark G. Rush and Peter D'Eustachio New York University School o/Medicine. Department,o/Biochemistry New York NY 10016 ABSTRACT GTPases, proteins that bind and hydrolyze GTP (guanosine triphos- phate) are critical regulators of many metabolic pathways. Although these proteins are enzymes that catalyze the hydrolysis of GTP to GDP + Pi, their primary function is not the hydrolysis of GTP per se, but rather the coupling of this hydrolysis to metabolic regulation. Such coupling is gen- erally achieved through the interaction of the GTP-bound form of the GTPase with proteins known as *effectors. Effectors are often enzymes whose activities are modulated by the GTPase. However, effectors can also be structural proteins involved in assembling intracellular macromo- lecular complexes, such as actin filaments and microtubules, as well as proteins involved in the intracellular transport of proteins and RNAs. In- deed, the subject of this anthology, the small GTPase Ran, may exert most or all of its regulatory functions by interacting with non-enzyme effectors. This property of Ran distinguishes it from other well studied GTPases, and has resulted in the elucidation of novel mechanisms of Ran action that are quite distinct from previously established paradigms of GTPase function. 1. INTRODUCTION The Ras-related nuclear protein Ran is a highly conserved (80% identity among yeasts and humans) member of the Ras superfamily of small GTP binding and hydrolyzing proteins.

For courses in managerial economics. Teaching students managerial economics through real examples, real businesses, with real-life situations The Economics of Managerial Decisions, 1st Edition teaches students how to make business decisions by blending the qualitative and quantitative aspects of the course. Using examples from different sectors of the economy, the authors present real examples, such as Pizza Hut, to teach the concepts of production and cost, and KV Pharmaceuticals, to talk about monopoly -- helping students see how theory is applied in different contexts. Students learn these skills and then master them using Auto-Graded Excel Projects and Decision-Making Mini-Sims within the accompanying MyLab (TM), to ensure they not only understand, but can also apply, the economics of making a managerial decision. Also available with MyLab Economics MyLab (TM) is the teaching and learning platform that empowers you to reach every student. By combining trusted authors' content with digital tools and a flexible platform, MyLab personalizes the learning experience and improves results for each student. Note: You are purchasing a standalone product; MyLab Economics does not come packaged with this content. Students, if interested in purchasing this title with MyLab, ask your instructor to confirm the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and MyLab Economics search for: 0134640985 / 9780134640983 Economics of Managerial Decisions Plus MyLab Economics with Pearson eText, The -- Access Card Package, 1/e Package consists of: 0133548236 / 9780133548235 Economics of Managerial Decisions, The 0134184696 / 9780134184692 MyLab Economics with Pearson eText -- Standalone Access Card -- for The Economics of Managerial Decisions