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Angiogenesis is the growth of new blood vessels and is a key
process which occurs during pathological disease progression.
Excessive and damaging angiogenesis occurs in diseases such as
cancer, diabetic retinopathies, age-related macular degeneration
and atherosclerosis. In other diseases such as stroke and
myocardial infarction, insufficient or improper angiogenesis
results in tissue loss and ultimately higher morbidity and
mortality. In this book we will begin by providing the reader with
an overview of the process of angiogenesis including normal
embryological development of blood vessels. The following chapters
will each focus on a key angiogenic disease incorporating current
scientific knowledge concerning the causes of activation of the
"angiogenic switch," pathological consequences, current treatment
options and future perspectives. Where appropriate, results from
pre-clinical trials, novel imaging modalities and nanotechnological
approaches will be incorporated into these sections. Finally, since
it is now believed that the process of angiogenesis operated via
different signalling mechanisms in different vascular beds, we will
discuss our current understanding of this phenomenon. The target
audience for this book would include researchers in all the basic
sciences; post-graduate students at Universities and Institutes;
pharmaceutical industries; clinicians working in vascular biology
or tissue imaging; pathologists; neurologists; tumour biologists;
ophthalmologists and cardiologists.
A wide range of research methods for the study of vascular
development, from basic laboratory protocols to advanced
technologies used in clinical practice, are covered in this work. A
range of methodologies such as molecular imaging platforms and
signalling analysis, along with tumour models are collated here.
Four sections explore in vitro techniques, in vivo and ex vivo
manipulations, imaging and histological analysis and other novel
techniques in vascular biology. Readers will discover basic
methodologies used for analysis of endothelial cell growth in
vitro, including co-culture models of vessel formation. Authors
also explore isolation and purification of cells and methods for
analysis of data and visualization of localized vasculature with
modern imaging platforms. Both animal models and human disease are
covered in this work. Each chapter contains helpful sections on
trouble shooting, additional notes and links, supporting the reader
to carry out protocols. This book will appeal to students,
researchers and medical professionals working in all
vascular-linked fields such as cardio- and cerebrovascular, cancer
and dementia.
Angiogenesis is the growth of new blood vessels and is a key
process which occurs during pathological disease progression.
Excessive and damaging angiogenesis occurs in diseases such as
cancer, diabetic retinopathies, age-related macular degeneration
and atherosclerosis. In other diseases such as stroke and
myocardial infarction, insufficient or improper angiogenesis
results in tissue loss and ultimately higher morbidity and
mortality. In this book we will begin by providing the reader with
an overview of the process of angiogenesis including normal
embryological development of blood vessels. The following chapters
will each focus on a key angiogenic disease incorporating current
scientific knowledge concerning the causes of activation of the
"angiogenic switch", pathological consequences, current treatment
options and future perspectives. Where appropriate, results from
pre-clinical trials, novel imaging modalities and nanotechnological
approaches will be incorporated into these sections. Finally, since
it is now believed that the process of angiogenesis operated via
different signalling mechanisms in different vascular beds, we will
discuss our current understanding of this phenomenon. The target
audience for this book would include researchers in all the basic
sciences; post-graduate students at Universities and Institutes;
pharmaceutical industries; clinicians working in vascular biology
or tissue imaging; pathologists; neurologists; tumour biologists;
ophthalmologists and cardiologists.
An advanced study which presumes a knowledge of multiple regression
and factor analysis techniques, this paper considers two techniques
for comparing entire sets of data, and develops the canonical
correlation model as an extension of regression analysis in which
there are several dependent variables.
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