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In this compilation, the authors begin with a review of the
mechanisms of synthesis and secretion, cellular effects and the
involvement of serotonin (5-HT) in physiological and behavioral
functions horses. In addition, the pathological conditions in which
5-HT is involved at the level of equine clinics are studied.
Following this, the capabilities and limitations of PET imaging
research on non-human primates are discussed for translation to
brain DA research on humans, as well as therapeutic drug
development for neurodegenerative diseases. This book also examines
the etiology of autism spectrum disorder (ASD). The authors present
available data contributing to the appreciation of a serotonergic
dysfunction in ASD, as well as discuss new avenues to reveal the
pathophysiology of this multifactorial disorder. Next, they review
the historical and current evidence that links neurotransmitters
with hemopoeitic stem cell mobilization, trafficking, and specially
emphasize the role of serotonin in erythropoiesis. Potential
actionable myelodysplastic and leukemic pathways are described and
investigated.
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