With the advancement in processing power and storage now enabling algorithms to expand their capabilities beyond their initial narrow applications, technology is becoming increasingly powerful. This highly topical Handbook provides a comprehensive overview of the impact of Artificial Intelligence (AI) on work, assessing its impact on an array of economic sectors, their resulting nature of work, and the subsequent policy implications of these changes. Featuring contributions from leading experts across diverse fields, the Handbook of Artificial Intelligence at Work takes an interdisciplinary approach to understanding AI’s connections to existing economic, social, and political ecosystems. Considering a range of fields including agriculture, manufacturing, health care, education, law and government, the Handbook provides detailed sector-specific analyses of how AI is changing the nature of work, the challenges it presents and the opportunities it creates. Looking forward, it makes policy recommendations to address concerns, such as the potential displacement of some human labor by AI and growth in inequality affecting those lacking the necessary skills to interact with these technologies or without opportunities to do so. This vital Handbook is an essential read for students and academics in the fields of business and management, information technology, AI, and public policy. It will also be highly informative from a cross-disciplinary perspective for practitioners, as well as policy makers with an interest in the development of AI technology.