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Given the immense progress achieved in elucidating protein protein
complex structures and in the field of protein interaction
modeling, there is great demand for a book that gives interested
researchers/students a comprehensive overview of the field. This
book does just that. It focuses on what can be learned about
protein protein interactions from the analysis of protein protein
complex structures and interfaces. What are the driving forces for
protein protein association? How can we extract the mechanism of
specific recognition from studying protein protein interfaces? How
can this knowledge be used to predict and design protein protein
interactions (interaction regions and complex structures)? What
methods are currently employed to design protein protein
interactions, and how can we influence protein protein interactions
by mutagenesis and small-molecule drugs or peptide mimetics? The
book consists of about 15 review chapters, written by experts, on
the characterization of protein protein interfaces, structure
determination of protein complexes (by NMR and X-ray), theory of
protein protein binding, dynamics of protein interfaces,
bioinformatics methods to predict interaction regions, and
prediction of protein protein complex structures (docking and
homology modeling of complexes, etc.) and design of protein protein
interactions. It serves as a bridge between studying/analyzing
protein protein complex structures (interfaces), predicting
interactions, and influencing/designing interactions.
Given the immense progress achieved in elucidating protein protein
complex structures and in the field of protein interaction
modeling, there is great demand for a book that gives interested
researchers/students a comprehensive overview of the field. This
book does just that. It focuses on what can be learned about
protein protein interactions from the analysis of protein protein
complex structures and interfaces. What are the driving forces for
protein protein association? How can we extract the mechanism of
specific recognition from studying protein protein interfaces? How
can this knowledge be used to predict and design protein protein
interactions (interaction regions and complex structures)? What
methods are currently employed to design protein protein
interactions, and how can we influence protein protein interactions
by mutagenesis and small-molecule drugs or peptide mimetics? The
book consists of about 15 review chapters, written by experts, on
the characterization of protein protein interfaces, structure
determination of protein complexes (by NMR and X-ray), theory of
protein protein binding, dynamics of protein interfaces,
bioinformatics methods to predict interaction regions, and
prediction of protein protein complex structures (docking and
homology modeling of complexes, etc.) and design of protein protein
interactions. It serves as a bridge between studying/analyzing
protein protein complex structures (interfaces), predicting
interactions, and influencing/designing interactions.
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