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This comprehensive review provides a systematic, unbiased analysis,
critique and summary of the available literature and generates
novel clinical decision-making algorithms which can aid clinicians
and scientists in practice management and research development.
Potential mechanisms for the identified drug interactions are
deduced from available preclinical and in vitro data which are
interpreted in the context of the in vivo findings. Current
limitations and gaps in the literature are summarized, and
potential future research directions / experimentations are also
suggested. In addition to the main objective to review the
available clinical pharmacokinetic and pharmacodynamic drug
interactions associated with WHO-recommended antimalarial drugs on
the market today (i.e. chloroquine, amodiaquine, sulfadoxine,
pyrimethamine, mefloquine, artemisinin, artemether, artesunate,
dihydroartemisinin, artemotil, lumefantrine, primaquine,
atovaquone, proguanil, piperaquine and quinine), this book also
provides succinct chapter summaries on the epidemiology of malaria
infection, diagnosis and therapeutics, in vivo pharmacology and
chemistry, preclinical pharmacology, in vitro pharmacodynamics, in
vitro reaction phenotyping, and in vitro drug-drug interaction data
associated with the identified antimalarial drugs.
This comprehensive review provides a systematic, unbiased analysis,
critique and summary of the available literature and generates
novel clinical decision-making algorithms which can aid clinicians
and scientists in practice management and research development.
Potential mechanisms for the identified drug interactions are
deduced from available preclinical and in vitro data which are
interpreted in the context of the in vivo findings. Current
limitations and gaps in the literature are summarized, and
potential future research directions / experimentations are also
suggested. In addition to the main objective to review the
available clinical pharmacokinetic and pharmacodynamic drug
interactions associated with WHO-recommended antimalarial drugs on
the market today (i.e. chloroquine, amodiaquine, sulfadoxine,
pyrimethamine, mefloquine, artemisinin, artemether, artesunate,
dihydroartemisinin, artemotil, lumefantrine, primaquine,
atovaquone, proguanil, piperaquine and quinine), this book also
provides succinct chapter summaries on the epidemiology of malaria
infection, diagnosis and therapeutics, in vivo pharmacology and
chemistry, preclinical pharmacology, in vitro pharmacodynamics, in
vitro reaction phenotyping, and in vitro drug-drug interaction data
associated with the identified antimalarial drugs.
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