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Proteopathic Seeds and Neurodegenerative Diseases (Paperback, 2013 ed.): Mathias Jucker, Yves Christen Proteopathic Seeds and Neurodegenerative Diseases (Paperback, 2013 ed.)
Mathias Jucker, Yves Christen
R4,949 Discovery Miles 49 490 Ships in 10 - 15 working days

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer's disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimers disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society.

Proteopathic Seeds and Neurodegenerative Diseases (Hardcover, 2013 ed.): Mathias Jucker, Yves Christen Proteopathic Seeds and Neurodegenerative Diseases (Hardcover, 2013 ed.)
Mathias Jucker, Yves Christen
R5,257 Discovery Miles 52 570 Ships in 10 - 15 working days

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimers disease, Parkinson s disease, Huntington s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. "

Alzheimer: 100 Years and Beyond (Paperback, Softcover reprint of hardcover 1st ed. 2006): Mathias Jucker, Konrad Beyreuther,... Alzheimer: 100 Years and Beyond (Paperback, Softcover reprint of hardcover 1st ed. 2006)
Mathias Jucker, Konrad Beyreuther, Christian Haass, Roger M. Nitsch
R8,649 Discovery Miles 86 490 Ships in 10 - 15 working days

Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in T bingen.

The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiation of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, was the highlight of the Year of Alzheimer. However, beyond these few months of tributes, the centennial offers a unique opportunity to assess both the progress achieved and the uncertainties remaining. This volume, a collection comprised mainly of articles by the invited speakers and also of a few other prominent researchers, is meant to be a record of those events.

Alzheimer: 100 Years and Beyond (Hardcover, 2006 ed.): Mathias Jucker, Konrad Beyreuther, Christian Haass, Roger M. Nitsch Alzheimer: 100 Years and Beyond (Hardcover, 2006 ed.)
Mathias Jucker, Konrad Beyreuther, Christian Haass, Roger M. Nitsch
R8,703 Discovery Miles 87 030 Ships in 10 - 15 working days

Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in T bingen.

The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiation of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, was the highlight of the Year of Alzheimer. However, beyond these few months of tributes, the centennial offers a unique opportunity to assess both the progress achieved and the uncertainties remaining. This volume, a collection comprised mainly of articles by the invited speakers and also of a few other prominent researchers, is meant to be a record of those events.

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