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JAK tyrosine kinases and STAT transcription factors constitute a
signaling pathway, which is activated by cytokines. By activating
gene transcription it regulates essential biological responses to
environmental cues. The Jak-Stat pathway is involved in the
regulation of cell development, differentiation, proliferation and
apoptosis. Improper function may contribute to hematopoietic
malignancies and cancer. This book provides comprehensive insights
into the latest basic and clinical developments in the field. The
first part reviews recent findings and new technologies pertaining
to basics of Jak-Stat function. The second part describes the
evolution of Jak-Stat signaling and the role of the pathway in
invertebrate organisms. The third part focuses on Jak-Stat
signaling in hematopoietic cells under both physiological and
pathophysiological conditions. Finally, chapters in the fourth
section describe the relationship of Jak-Stat signaling to various
states of disease, particularly infection, leukemias and solid
cancers. The book is intended for all scientists in molecular
biology, biochemistry and cell biology dealing with biomedical
issues.
JAK tyrosine kinases and STAT transcription factors constitute a
signaling pathway, which is activated by cytokines. By activating
gene transcription it regulates essential biological responses to
environmental cues. The Jak-Stat pathway is involved in the
regulation of cell development, differentiation, proliferation and
apoptosis. Improper function may contribute to hematopoietic
malignancies and cancer. This book provides comprehensive insights
into the latest basic and clinical developments in the field. The
first part reviews recent findings and new technologies pertaining
to basics of Jak-Stat function. The second part describes the
evolution of Jak-Stat signaling and the role of the pathway in
invertebrate organisms. The third part focuses on Jak-Stat
signaling in hematopoietic cells under both physiological and
pathophysiological conditions. Finally, chapters in the fourth
section describe the relationship of Jak-Stat signaling to various
states of disease, particularly infection, leukemias and solid
cancers. The book is intended for all scientists in molecular
biology, biochemistry and cell biology dealing with biomedical
issues.
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