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This book puts hydrogen sulfide in context with other gaseous
mediators such as nitric oxide and carbon monoxide, reviews the
available mechanisms for its biosynthesis and describes its
physiological and pathophysiological roles in a wide variety of
disease states. Hydrogen sulfide has recently been discovered to be
a naturally occurring gaseous mediator in the body. Over a
relatively short period of time this evanescent gas has been
revealed to play key roles in a range of physiological processes
including control of blood vessel caliber and hence blood pressure
and in the regulation of nerve function both in the brain and the
periphery. Disorders concerning the biosynthesis or activity of
hydrogen sulfide may also predispose the body to disease states
such as inflammation, cardiovascular and neurological disorders.
Interest in this novel gas has been high in recent years and many
research groups worldwide have described its individual biological
effects. Moreover, medicinal chemists are beginning to synthesize
novel organic molecules that release this gas at defined rates with
a view to exploiting these new compounds for therapeutic benefit.
This book puts hydrogen sulfide in context with other gaseous
mediators such as nitric oxide and carbon monoxide, reviews the
available mechanisms for its biosynthesis and describes its
physiological and pathophysiological roles in a wide variety of
disease states. Hydrogen sulfide has recently been discovered to be
a naturally occurring gaseous mediator in the body. Over a
relatively short period of time this evanescent gas has been
revealed to play key roles in a range of physiological processes
including control of blood vessel caliber and hence blood pressure
and in the regulation of nerve function both in the brain and the
periphery. Disorders concerning the biosynthesis or activity of
hydrogen sulfide may also predispose the body to disease states
such as inflammation, cardiovascular and neurological disorders.
Interest in this novel gas has been high in recent years and many
research groups worldwide have described its individual biological
effects. Moreover, medicinal chemists are beginning to synthesize
novel organic molecules that release this gas at defined rates with
a view to exploiting these new compounds for therapeutic benefit.
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