Updated and expanded, this Second Edition of Essentials of Clinical Radiation Oncology continues to provide a succinct and effective review of the most important studies in the field. Organized by disease topic and grouped by body part, each chapter employs structured sections for targeted information retrieval and retention. Chapters begin with a "Quick Hit" overview of each disease summarizing the most significant paradigms before moving into dedicated summaries on epidemiology, risk factors, anatomy, pathology, genetics, screening, clinical presentation, workup, prognostic factors, staging, treatment paradigm, and medical management. An evidence-based question and answer section concludes each chapter, which pairs commonly encountered clinical questions with answers connecting historical context and pertinent clinical studies to better inform decision making and treatment planning.Providing the latest treatment paradigms and guidelines, this comprehensive second edition now outlines the evidence and must-know considerations for using radiation therapy with immunotherapy, the strategies for metastasis-directed therapy for oligometastatic disease, and much more. Written for the practicing radiation oncologist, related practitioner, and radiation oncology resident entering the field, this "one-stop" resource is the go-to reference for everyday practice. Key Features: Structured sections offer high-yield information for targeted review Cites need-to-know clinical studies and treatment guidelines in evidence-based question and answer format Each chapter has been reviewed and updated to include the most recent and relevant studies New chapters on spine tumors, thyroid cancer, sinonasal tumors, cholangiocarcinoma, renal cell carcinoma, multiple myeloma and plasmacytoma, miscellaneous pediatric tumors, and treatment of oligometastatic disease from underlying cancers Designed for quick reference with comprehensive tables on treatment options and patient selection, workup, and prognostic factors by disease site Purchase includes digital access for use on most mobile devices or computers

For western colonists in the early American backcountry, disputes often ended in bloodshed and death. Making the Frontier Man examines early life and the origins of lawless behavior in Pennsylvania, Virginia, Kentucky, and Ohio from 1750 to 1815. It provides a key to understanding why the trans-Appalachian West was prone to violent struggles, especially between white men. Traumatic experiences of the Revolution and the Forty Years War legitimized killing as a means of self-defense—of property, reputation, and rights—transferring power from the county courts to the ordinary citizen. Backcountry men waged war against American Indians in state-sponsored militias as they worked to establish farms and seize property in the West. And white neighbors declared war on each other, often taking extreme measures to resolve petty disputes that ended with infamous family feuds. Making the Frontier Man focuses on these experiences of western expansion and how they influenced American culture and society, specifically the nature of western manhood, which radically transformed in the North American environment. In search of independence and improvement, the new American man was also destitute, frustrated by the economic and political power of his elite counterparts, and undermined by failure. He was aggressive, misogynistic, racist, and violent, and looked to reclaim his dominance and masculinity by any means necessary. face=Calibri>

Even as the 250th anniversary of its outbreak approaches, the Seven Years' War (otherwise known as the French and Indian War) is still not wholly understood. Most accounts tell the story as a military struggle between British and French forces, with shifting alliances of Indians, culminating in the British conquest of Canada. Scholarly and popular works alike, including James Fennimore Cooper's Last of the Mohicans, focus on the action in the Hudson River Valley and the St. Lawrence Seaway. Matthew C. Ward tells the compelling story of the war from the point of view of the region where it actually began, and whose people felt the devastating effects of war most keenly-the backcountry communities of Virginia and Pennsylvania. Previous wars in North America had been fought largely on the New England and New York frontiers. But on May 28, 1754, when a young George Washington commanded the first shot fired in western Pennsylvania, fighting spread for the first time to Virginia and Pennsylvania. Ward's original research reveals that on the eve of the Seven Years' War the communities of these colonies were isolated, economically weak, and culturally diverse. He shows in riveting detail how, despite the British empire's triumph, the war brought social chaos, sickness, hunger, punishment, and violence, to the backcountry, much of it at the hands of Indian warriors. Ward's fresh analysis reveals that Indian raids were not random skirmishes, but part of an organized strategy that included psychological warfare designed to make settlers flee Indian territories. It was the awesome effectiveness of this “guerilla” warfare, Ward argues, that led to the most enduring legacies of the war: Indian-hating and an armed population of colonial settlers, distrustful of the British empire that couldn't protect them. Understanding the horrors of the Seven Years' War as experienced in the backwoods thus provides unique insights into the origins of the American republic.