Although rare, retinoblastoma has been at the fore- fortunate; while in the developed world eye preser- front of cancer research and treatment for the last tion has become a priority, developing countries c- three decades. The two-hit hypothesis of oncogenesis tinue to face delays in diagnosis, poor access to care, proposed by Alfred Knudson provided the conceptual and suboptimal treatment - the problem in the less framework for tumor suppressor gene research and developed world is cure. led to the discovery of the retinoblastoma pathway as In this book, we have invited a team of experts to a key element in cancer development. More recently, address all those important aspects of retinoblastoma the treatment of children with retinoblastoma has also research and therapy - from biology to epidemiology provided a model for modern approach to the can- to treatment. We hope that in subsequent editions we cer patient; state of the art retinoblastoma treatment will be able to continue to provide updates on such can only be conceived in the context of the multidis- exciting subjects.

Beyond Residency offers practical, no-nonsense advice about the business and economics of being a medical doctor. Used as a textbook in the Business of Medicine Course at East Carolina University's Brody School of Medicine, this edition is designed to work more broadly for other institutions teaching business of medicine courses and for new physicians starting out in practice. Recalling his days in medical school, Marc Lyles, senior director of health care affairs for the Association of American Medical Colleges said, ""Whenever we asked a business question we were always told, 'Don't worry about that. You need to learn the medical side before you worry about the business side.'"" He states that between 2003 and 2007, the majority of students were satisfied with their medical and clinical training. However, less than half felt that enough time was devoted to the practice of medicine, especially to medical economics. The Brody School of Medicine addresses that discrepancy, offering its Business of Medicine Course as a fourth-year elective and as a postgraduate class for students in the Department of Physical Medicine and Rehabilitation. Topics addressed include time value of money, contracts, RVUs, disability and life insurance, and investment plans such as traditional IRAs and Roth IRAs. In 2015, the Business of Medicine Course received a positive score of 4.68/5 (94%) for its value to medical students, and Beyond Residency received a score of 3.89/4 (97%) for its effectiveness in teaching students the business of medicine. Beyond Residency helps students to understand important yet under-explored areas that will impact them as practicing physicians.

New Lines takes the pulse of a society increasingly drawn to the power of the digital map, examining the conceptual and technical developments of the field of geographic information science as this work is refracted through a pervasive digital culture. Matthew W. Wilson draws together archival research on the birth of the digital map with a reconsideration of the critical turn in mapping and cartographic thought.  Seeking to bridge a foundational divide within the discipline of geography—between cultural and human geographers and practitioners of Geographic Information Systems (GIS)—Wilson suggests that GIS practitioners may operate within a critical vacuum and may not fully contend with their placement within broader networks, the politics of mapping, the rise of the digital humanities, the activist possibilities of appropriating GIS technologies, and more. Employing the concept of the drawn and traced line, Wilson treads the theoretical terrain of Deleuze, Guattari, and Gunnar Olsson while grounding their thoughts with the hybrid impulse of the more-than-human thought of Donna Haraway. What results is a series of interventions—fractures in the lines directing everyday life—that provide the reader with an opportunity to consider the renewed urgency of forceful geographic representation. These five fractures are criticality, digitality, movement, attention, and quantification. New Lines examines their traces to find their potential and their necessity in the face of our frenetic digital life.

New Lines takes the pulse of a society increasingly drawn to the power of the digital map, examining the conceptual and technical developments of the field of geographic information science as this work is refracted through a pervasive digital culture. Matthew W. Wilson draws together archival research on the birth of the digital map with a reconsideration of the critical turn in mapping and cartographic thought.  Seeking to bridge a foundational divide within the discipline of geography—between cultural and human geographers and practitioners of Geographic Information Systems (GIS)—Wilson suggests that GIS practitioners may operate within a critical vacuum and may not fully contend with their placement within broader networks, the politics of mapping, the rise of the digital humanities, the activist possibilities of appropriating GIS technologies, and more. Employing the concept of the drawn and traced line, Wilson treads the theoretical terrain of Deleuze, Guattari, and Gunnar Olsson while grounding their thoughts with the hybrid impulse of the more-than-human thought of Donna Haraway. What results is a series of interventions—fractures in the lines directing everyday life—that provide the reader with an opportunity to consider the renewed urgency of forceful geographic representation. These five fractures are criticality, digitality, movement, attention, and quantification. New Lines examines their traces to find their potential and their necessity in the face of our frenetic digital life.