This book constitutes the thoroughly refereed post-conference proceedings of the 4th International ICST Conference on e-Infrastructure and e-Services for Developing Countries, AFRICOMM 2012, held in Yaounde, Cameroon, in November 2012. The 24 revised full papers presented were carefully reviewed and selected from numerous submissions. The papers cover a wide range of topics in the field of information and communication infrastructures and are grouped in topical sections on: e-Infrastructure, e-Services, e-Society, e-Health, and e-Security.