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Over the last ten years, much effort has been devoted to improving
the biophysical techniques used in the study of viruses. This has
resulted in the visualization of these large macromolecular
assemblages at atomic level, thus providing the platform for
functional interpretation and therapeutic design. Structural
Virology covers a wide range of topics and is split into three
sections. The first discusses the vast biophysical methodologies
used in structural virology, including sample production and
purification, confocal microscopy, mass spectrometry,
negative-stain and cryo-electron microscopy, X-ray crystallography
and nuclear magnetic resonance spectroscopy. The second discusses
the role of virus capsid protein structures in determining the
functional roles required for receptor recognition, cellular entry,
capsid assembly, genome packaging and mechanisms of host immune
system evasion. The last section discusses therapeutic strategies
based on virus protein structures, including the design of
antiviral drugs and the development of viral capsids as vehicles
for foreign gene delivery. Each topic covered will begin with a
review of the current literature followed by a more detailed
discussion of experimental procedures, a step in the viral life
cycle, or strategies for therapeutic development. With
contributions from experts in the field of structural biology and
virology this exceptional monograph will appeal to biomedical
scientists involved in basic and /or applied research on viruses.
It also provides up-to-date reference material for students
entering the field of structural virology as well as scientists
already familiar with the area.
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