This book constitutes the proceedings of the 22nd International Working Conference on Requirements Engineering - Foundation for Software Quality, REFSQ 2016, held in Gothenburg, Sweden, in March 2016. The 16 full papers and 5 short papers presented in this volume were carefully reviewed and selected from 64 submissions. The papers were organized in topical sections named: decision making in requirements engineering; open source in requirements engineering; natural language; compliance in requirements engineering; requirements engineering in the automotive domain; empirical studies in requirements engineering; requirements engineering foundations; human factors in requirements engineering; and research methodology in requirements engineering.