Drug repurposing, or drug repositioning, or reprofi ling, has emerged as a valid approach in modern drug discovery. The book describes tools and techniques for identifying new therapeutic potentials for existing drugs and covers the repurposing of drugs from synthetic and natural origin. It compares the costs of drug repurposing with traditional drug discovery and discusses challenges and future perspectives of drug repurposing.

This volume brings together cutting-edge laboratory protocols to characterize the novel fluorescent proteins (FPs) and approaches based on fluorescent proteins that aim to answer some of the key cell biological questions. The book covers topics ranging from the database of fluorescent proteins to their characterization and adaptation to a wide range of biological systems. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Fluorescent Proteins: Methods and Protocols serves as an ideal guide for students and academicians enthusiastic about the recent progress in the practical application of fluorescent protein technology.

The general ledger is the backbone of your financials system. Learn everything you need for configuring and using the general ledger in SAP S/4HANA. Walk step by step through setting up fiscal years, posting periods, parallel ledgers, and more. See routine processes like posting, document control, and year-end closing in action. Whether you're planning a new implementation or a system conversion, this is your complete guide to general ledger accounting in SAP S/4HANA! Highlights include: 1) Posting periods 2) Parallel reporting 3) Currencies 4) Master data 5) Profit center accounting 6) Document splitting, posting, and clearing 7) Cost of sales accounting 8) Financial close 9) Accruals management 10) Reporting and analytics 11) Central Finance