When pneumonia lands Estelle Trager unconscious in the emergency room, it ruins everything for the stubborn 65-year-old woman. She'd been keeping a secret-a deadly secret-that she'd planned on taking to the grave. But now her son Adam and his wife, Liza, know about her tumors. Adam is outraged, but Estelle, who watched her mother and grandmother suffer from breast cancer in the days when no one dared speak its name, has no intention of putting her family or herself through the horrors of cancer treatment. Estelle decides there is only one solution: ask Liza, the 33-year-old daughter-in-law she once called a godless hippie raised by wolves, to kill her. A horrified Liza refuses and keeps the request-among other things-a secret from her furious husband. But she tells his younger brother, Charlie, a close friend from college with whom she shares her own confidences, despite Adam's serious case of sibling rivalry. Armed with nutrition textbooks and her neighbor, a savvy nurse, can Liza win over her mother-in-law and convince her to consider other options before the cancer, the secrets, and Estelle's determination to end her life win out?