The Legitimacy of European Constitutional Orders is a systematic and comparative study of European constitutional orders, taking into consideration the national constitutional traditions of European countries, as well as the defining power of EU law. Drawing on a wealth of case studies, this book explores the trajectories followed by European national constitutional orders in their efforts to attain legitimacy. More in particular, the book investigates Bruce Ackerman’s influential world constitutionalism project and engages with the three legitimacy pathways put forward therein; that is, the revolutionary, the establishment, and the elite pathways. Such ideal trajectories are revisited and found in need of being questioned so as to furnish the conceptual tools essential in the efforts of reconstructing and assessing the European constitutional orders. The book also considers the relevance of constitutional transformation and change in comparative constitutional law, and accounts for the manifold impacts of the European integration process on national constitutional trajectories. Offering an original perspective on the issue of constitutional legitimacy in the European context, this comprehensive book will be of interest to scholars and students of comparative law, constitutional law, European law, political science and constitutional theory as well as researchers and practitioners in these fields.

With significant changes to public funding and the rise of litigants in person, many practitioners are looking to provide services on a 'pay as you go' or 'fixed fee' basis for discrete or separate pieces of work. 'Unbundling' is an approach whereby the solicitor and client agree which parts of the process the client can undertake without assistance, and which parts they will require some input from a solicitor. This approach is growing in the area of family law. This toolkit provides a suite of tools to assist family solicitors considering unbundling work and new methods of pricing while pointing out the potential risks and how to minimize them. Practical and concise, it contains useful templates and checklists for solicitors wishing to offer unbundled services as a more affordable alternative to the traditional retainer and hourly rates pricing strategy.

Medicinal Chemistry of Anticancer Drugs, Third Edition provides an updated resource for students and researchers from the point-of-view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. The new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point-of-view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references, reviews and primary literature.

Everything there is to know about avocados is here: ancient origins, amazing health properties, restorative cosmetic uses, and a recipe collection far beyond the tried and true. This book features a fresh visual design aesthetic that reflects the creative sensibility of Mexican contemporary art, graphic design, atmospheric photography, and street style. Recipes cover everything from guacamole in many variations, salads, unusual sides, many permutations of avocado toast even toastless avocado sandwiches as well as less well-known and offbeat uses. The book also explores avocado butter and oil; detoxifying smoothies; rejuvenating cosmetic salves and masks, and much more. Practical matters are also addressed: an avocado overview by type; storage tips; preserving the brilliant green flesh from browning; ripening immature fruits; and safety tips for slicing and de-pitting. Avocados are grown in Mediterranean climates globally and dominate social media, hip restaurant menus, and health-based diets, but this is the first book paying tribute to the superfruit s deep roots as a native, Mexican heritage food.

Sustainable development is a process to improve the quality of life of people, while maintaining the ability of social–ecological systems to continue to provide valuable ecological services that social systems require. In the Galapagos Islands, the maintenance of amenity resources to support tourism and the quality of life of residents is explicitly linked to ecosystem goods and services, particularly, the accessibility to high-quality natural environments and the terrestrial and marine visitation sites that showcase iconic species. On June 26-30, 2022, the Galapagos Science Center celebrated its 10-Year Anniversary. As the crowning event of the anniversary celebration, the World Summit on Island Sustainability was held on San Cristobal Island, Galapagos Archipelago of Ecuador. The intent of the World Summit was to bring together leading experts on island ecosystems and, particularly, on island sustainability from across the globe to represent a diversity of perspectives, approaches, and stakeholder groups. The World Summit was an exclusive event that featured an “expert convening� of scholars and practitioners to address the social, terrestrial, and marine sub-systems of the Galapagos Islands and other similarly challenged island ecosystems from around the globe. The World Summit attracted 150 scientists to the Galapagos Islands to discuss projects conducted, for instance, in the Galapagos Islands, Hawaii, Guam, French Polynesia, Chile, Australia, and the Caribbean Islands. Island vulnerability, resilience, and sustainability were examined by scholars, for instance, from the University of North Carolina at Chapel Hill, Universidad San Francisco de Quito, Catholic University of Chile, University of Guam, James Cook University, University of the Sunshine Coast, North Carolina State University, North Carolina Museum of Natural Sciences, California Academy of Sciences, University of San Francisco, and the University of South Alabama as well as affiliated scientists from Exeter University, University of Edinburgh, University of Southampton, and the Galapagos National Park.  The World Summit also included scholars from Re:wild, World Wildlife Fund, EarthEcho, and the East-West Center, Hawaii.