There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

The fully revised, third edition of this bestselling handbook describes best practice of critical care in a succint, concise, and clinically-oriented way. Covering the principles of general management, it includes therapeutic and monitoring devices, specific disorders of organ systems, as well as detailed information on drugs and fluids. New material has been added on key areas such as airway maintenance, dressing techniques, infection control, echocardiography, tissue perfusion monitoring, coma and more. With up-to-date references and invaluable clinical advice, there is also plenty of space to add notes or amend sections to suit local protocols.
Patient-centered and practical, it will serve the consultant, trainee, nurse or other allied health professionals as both a reference and aide memoir. This is the indispensable Oxford Handbook for all those working within critical care.

This issue of Critical Care Clinics, edited by Mervyn singer and Manu Shankar-Hari, includes: Sepsis 3.0 Definitions; Epidemiology and Outcomes; Pathophysiology of sepsis; Pathophysiology of Septic shock; Mechanism of organ dysfunction in sepsis; Endocrine and metabolic alterations in sepsis: challenges and treatments; The immune system in sepsis; Nutrition and Sepsis; Common sense approach to managing sepsis; Biomarkers for sepsis and their use; Personalizing sepsis care; Novel interventions - What's new and the future; and Long term outcomes following Sepsis.

This excellent value pack contains the Oxford Handbook of Critical Care Third Edition and Emergencies in Critical Care Second Edition. The combination of practical advice and essential background information with an easily accessible guide in emergencies presents a unique package essential to every doctor with an interest in Critical Care. The fully revised, third edition of the Oxford Handbook of Critical Care describes best practice of critical care in a succinct, concise and clinically-orientated way. Covering the principles of general management, it includes therapeutic and monitoring devices, specific disorders of organ systems, as well as detailed information on drugs and fluids. New material has been added on key areas such as airway maintenance, dressing techniques, infection control, echocardiography, tissue perfusion monitoring, coma and more. With up-to-date references and invaluable clinical advice, there is also plenty of space to add notes or amend sections to suit local protocols. Emergencies in Critical Care provides a practical, accessible guide to all emergency situations encountered in the critical care setting. Emergencies are very common in the critical care setting; but also surprisingly predictable. This book helps critical care staff identify those at risk, how to manage them, and be prepared in the ward. This second edition covers new areas of importance, including sections on how to deal with adverse events and critical incidents involving critically ill patients, patient-safety and improved patient rescue packages, and on the practicalities of infection control procedures. Normal values have been combined into one short chapter for easy reference. Easy to use and evidence based, this book will help all critical care staff involved with the management of emergencies, from the new junior doctor to the experienced consultant in a portable and easily-readable format.