An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

There is a little Neanderthal in all of us. Although they have been extinct for 40,000 years, our genetic inheritance means that they are not entirely gone. Since the publication of the first Neanderthal genome in 2010, our understanding of the Neanderthals - and our connection to them - has changed dramatically. Once stereotyped as simple and brutish, recent discoveries by archaeologists and geneticists have painted a different picture of Neanderthals, and one more familiar to us: they buried their dead, cared for the sick, and even painted cave walls. We can now delve into their DNA to trace their evolution in Europe and movements across Asia, and piece together how they lived and died in amazing detail. This fully updated edition presents cutting-edge research on our fascinating hominin relatives: their interbreeding with humans and other species including the recently discovered Denisovans, their social behaviours such as smiling to indicate friendliness, and the genes they have passed down to us that could be affecting our health. By confronting our differences and similarities to the Neanderthals, this book addresses the biggest question of all: what it means to be human.

An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

This book reveals how the Celts came to Britain in the sense of how the term 'Celtic' first became associated with the British Isles in the eighteenth century and then gradually took on its modern popular meaning towards the end of the nineteenth. The role of the druids and the importance of craniology in this process is emphasised.