The effective theory of quantum gravity coupled to models of particle physics is being probed by cutting edge experiments in both high energy physics (searches for extra dimensions) and cosmology (testing models of inflation). This thesis derives new bounds that may be placed on these models both theoretically and experimentally. In models of extra dimensions, the internal consistency of the theories at high energies are investigated via perturbative unitarity bounds. Similarly it is shown that recent models of Higgs inflation suffer from a breakdown of perturbative unitarity during the inflationary period. In addition, the thesis uses the latest LHC data to derive the first ever experimental bound on the size of the Higgs boson's non-minimal coupling to gravity.

The effective theory of quantum gravity coupled to models of particle physics is being probed by cutting edge experiments in both high energy physics (searches for extra dimensions) and cosmology (testing models of inflation). This thesis derives new bounds that may be placed on these models both theoretically and experimentally. In models of extra dimensions, the internal consistency of the theories at high energies are investigated via perturbative unitarity bounds. Similarly it is shown that recent models of Higgs inflation suffer from a breakdown of perturbative unitarity during the inflationary period. In addition, the thesis uses the latest LHC data to derive the first ever experimental bound on the size of the Higgs boson's non-minimal coupling to gravity.

The Classic Text-Expanded, Updated...More Authoritative than Ever! Cutaneous Melanoma is the definitive and most authoritative textbook on melanoma used worldwide. This 5th edition provides the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma. Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition collectively incorporates the clinical outcomes of more than 60,000 patients treated at major melanoma centers throughout the world. Comprehensive Coverage-from Prevention to Advanced Treatment This new edition provides in-depth coverage, ranging from precursors of melanoma to advanced stages of metastatic disease; from melanoma genes to population-based epidemiology; and from prevention of melanoma to all forms of multidisciplinary treatments. Basic principles of diagnosis and pathologic examination are combined with treatment approaches for the many clinical presentations. Clinical management is supported by statistical data about natural history, prognosis, and treatment results. The latest information on staging and prognosis, as well as randomized prospective clinical trials involving surgical treatment and systemic treatments, is included. This volume presents a balanced perspective of the risks and benefits involved in each treatment modality. The book also contains: 1) a comprehensive color atlas of melanoma and its precursors, 2) illustrated surgical and perfusion techniques for every stage and anatomic location of melanoma, and 3) complex genetic and molecular pathways involving melanoma biology. Every drug and biologic agent in use today is described with indications and efficacy. Entirely Revised and Updated Seven new chapters discuss the emerging clinical data on the use of biomarkers, adjuvant therapies, targeted therapies, and immune modulation as well as significant clinical research advances in the clinical management of melanoma. The remaining 37 chapters have been extensively updated and revised to include the latest clinical, radiological, and pathological data and clinical trial advances. Cutaneous Melanoma, 5th Edition, retains the logical organization and clarity of expression responsible for its enduring popularity over the last 23 years. This volume will become an invaluable part of your library and a trusted resource that you will refer to again and again. The most comprehensive reference on melanoma available today! New Chapters Include: Clinical Genetics and Risk Assessment Sentinel Lymph Node and Regional Micrometastases Multidisciplinary Management of CNS Metastases Adjuvant Therapy for Cutaneous Melanoma Immune Modulation Therapy Using Anti-CTLA-4 Monoclonal Antibodies Melanoma-Specific Targeted Therapies Biomarkers for Cutaneous Melanoma