This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

Evidence-Based Treatment Approaches for Suicidal Adolescents: Translating Science Into Practice combines state-of-the-art research and treatment development with clinical descriptions of evidence-based and evidence-informed treatment strategies for adolescents struggling with suicidality and self-harm. The book provides important information on clinical approaches that have shown promise in reducing the risk of suicide attempts and self-harm in teens and preventing the tragedy of premature death by suicide. Following two chapters on risk assessment and safety planning, six chapters present different approaches to psychosocial treatment. Although some approaches share common theoretical roots, and most address similar targets and mechanisms (e.g., restricting access to lethal means of self-harm, enhancing family support and functioning, and strengthening emotion regulation), each treatment modality has important differences and distinct strengths. The book's final chapter addresses pharmacological strategies for managing and treating suicidality. This combination of information on risk assessment and management, safety planning, psychosocial treatment, and pharmacologic treatment reflects the perspective that psychosocial and biologically based risk and protective factors are increasingly recognized as crucial for improving the mental health of and outcomes for adolescents and their families. The volume's many useful features include the following: * The book is user-friendly. Each treatment chapter follows a common structure: overview, theoretical model, review of current empirical evidence, primary treatment components and intervention strategies, case example, recommendations for implementing the approach in practice, resources for obtaining training, and suggested readings. Readers can easily find relevant information and compare treatment approaches.* The book is practice friendly. By offering a review of existing evidence-based treatments for at-risk adolescents in one accessible volume, the book makes it easier for clinicians to learn about current findings in the field and to choose between existing approaches. Moreover, the clinically rich chapters contain case examples and suggestions for implementing each treatment into practice across a range of settings. * The book is pragmatic. Recognizing that clinicians attempting to implement these promising treatments in community practice with limited resources may encounter challenges, the authors include a table at the end of each treatment chapter describing elements that may more easily be put into practice when implementation of the full treatment protocol is not feasible.* The book emphasizes risk assessment and safety. Risk and protective factors are explored in-depth, as are strategies for enhancing safety. These strategies are relatively straightforward, but they have the enormous potential to save lives. An indispensable resource not only for clinicians working across diverse practice settings, Evidence-Based Treatment Approaches for Suicidal Adolescents: Translating Science Into Practice will also prove valuable to policy makers, health and behavioral health system leaders, and researchers engaged in the critically important work of reducing suicide among adolescents.

Recent studies regarding the neuropathology of specific neurological disorders suggest that both neurodevelopmental and neurodegenerative processes may play a role. However, in contrast to the neurodegeneration seen in neurological disorders such as Parkinson's and Alzheimer's disease, the term "neuroprogression" has been used to describe the neurodevelopmental aspect of pathological brain re-wiring that takes place in the context of severe psychiatric disorders, such as schizophrenia or bipolar disorder. Within psychiatry, patients with severe psychopathology, such as those depressed patients who eventually commit suicide, have been shown to present with increased inflammatory markers in the brain. A similar increase in inflammatory markers is also found in patients with bipolar disorders and schizophrenia. Thus, oxidative stress, inflammation, and changes in growth factors are thought to be the pathways of neuroprogression. Neuroprogression in Psychiatry provides a comprehensive summary of the current developments in the emerging field of neuroprogression. With contributions by leading researchers in the field, this book examines the role of neuroprogression across a wide range of specific psychiatric disorders, with chapters included on major depressive disorder, anxiety disorder, post-traumatic stress disorder, substance abuse, schizophrenia, and bipolar disorder.

After the original proposals of staging for psychotic disorders developed by McGorry and colleagues, a few systems have been put forward specifically for people with bipolar disorder. There is now consistent evidence that, at least for a significant portion of people with this disease, clinical course and outcome are not as benign as initially described. The evidence thus far points to relevant differences between early and late stages of bipolar disorders in the clinical course of illness, neurobiology and systemic pathology. These differences all suggest that staging is a viable addition to clinical care in bipolar disorder. Neuroprogression and Staging in Bipolar Disorder provides a comprehensive summary of the current state of the evidence regarding the use of staging systems in bipolar disorder. Edited by the leading researchers in the field, the book systematically covers the theoretical basis for staging, comparisons between different proposals, neurobiological underpinnings, the current evidence-base, limitations and future directions, and clinical implications and recommendations for practice. The book provides a solid and in-depth outline and thus to influence research and practice in the field of bipolar disorder.

As research emerges on the effectiveness of psychological therapies for bipolar disorder, this is the first manual guiding the treatment of those in adolescence and early adulthood, taking into account the developmental issues which can have significant impact on therapeutic outcomes. Core issues covered include engagement difficulties, how cognitive therapy should be adapted for adolescents, the impact of the disorder on the person's psychosocial development, managing comorbidity (particularly alcohol and substance use), medication adherence, the impact of family dynamics, and issues around control and independence in the therapeutic relationship. The manual is illustrated with case studies and text boxes describing tips and techniques for the therapist. Providing clear clinical guidance, backed by an extensive literature review and theoretical overview, this is essential reading for all mental health specialists implementing psychological interventions for young people with bipolar disorder.

Modern mental health issues are characterized by their complex, multi-systemic nature and broad societal impact, making them poorly suited to siloed approaches of thinking and innovation. Convergence science integrates knowledge, tools, and thought strategies from various fields and is the focal point where novel insights arise. Convergence Mental Health presents a blueprint for leveraging convergence science within the context of mental health in order to improve patient outcomes and health care systems.