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This timely and compact monograph addresses how to determine drug
permeability across the blood-brain barrier more effectively.
Focusing on the physiological mechanisms that influence the passage
of agents into the brain, the book covers the latest research on
the blood-brain barrier, the current problems of and solutions to
drug delivery to the central nervous system (CNS), existing
strategies, and prospects for future research. Avoid excessive in
vivo experimentation and utilize timesaving in vitro techniques. A
concise reference with reviews from nearly 40 international
specialists in diverse fields, The Blood-Brain Barrier and Drug
Delivery to the CNS assesses the properties of the blood-brain
barrier to determine and measure drug permeability in animals and
humans presents techniques to predict successful drug uptake
through in vitro systems or by computation of physicochemical
parameters examines the multidrug resistance protein P-glycoprotein
as a natural transporter analyzes current drug designs to known
requirements for transport looks at drug delivery systems for the
brain and much more! Densely packed with over 800 literature
references, drawings, photographs, x-rays, tables, and equations,
The Blood-Brain Barrier and Drug Delivery to the CNS is a vital
addition to the bookshelves of biochemists, pharmacists, clinical
and research pharmacologists, neuroscientists and neurologists, and
graduate and medical school students in these disciplines.
This timely and compact monograph addresses how to determine drug
permeability across the blood-brain barrier more effectively.
Focusing on the physiological mechanisms that influence the passage
of agents into the brain, the book covers the latest research on
the blood-brain barrier, the current problems of and solutions to
drug delivery to the central nervous system (CNS), existing
strategies, and prospects for future research. Avoid excessive in
vivo experimentation and utilize timesaving in vitro techniques. A
concise reference with reviews from nearly 40 international
specialists in diverse fields, The Blood-Brain Barrier and Drug
Delivery to the CNS -assesses the properties of the blood-brain
barrier to determine and measure drug permeability in animals and
humans -presents techniques to predict successful drug uptake
through in vitro systems or by computation of physicochemical
parameters -examines the multidrug resistance protein
P-glycoprotein as a natural transporter -analyzes current drug
designs to known requirements for transport -looks at drug delivery
systems for the brain -and much more! Densely packed with over 800
literature references, drawings, photographs, x-rays, tables, and
equations, The Blood-Brain Barrier and Drug Delivery to the CNS is
a vital addition to the bookshelves of biochemists, pharmacists,
clinical and research pharmacologists, neuroscientists and
neurologists, and graduate and medical school students in these
disciplines.
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