In recent years, a number of molecular pathways and cellular processes that are essential for normal vertebrate development have been implicated in cancer initiation and progression. In this volume, leaders in the field of cancer genetics and developmental biology share recent insights into the importance of developmental pathways for tumorigenesis. These discoveries provide important avenues for innovative new approaches to treating some of the most challenging developmental tumors.

Provides researchers an overview and synthesis of the latest research findings and contemporary thought in the area
There are now a large number of molecular targeted therapies for the treatment of cancer. Many of these therapies target pathways that are essential for normal development. Therefore, this volume provides an up to date and timely perspective on those pathways and biological processes that hold the greatest promise for targeted intervention.

For decades, the United States has led the effort to stem the spread of nuclear weapons, both among potential adversaries and among its allies and partners. The current state of deterrence and of the nonproliferation regime, however, is open to many doubts. What happens if the nonproliferation regime should break down altogether? What happens if extended deterrence should fail, and allies no longer believe in the credibility of the U.S. nuclear umbrella? What happens when the world has not 9 but 11, 15, 18, or even more nuclear powers? This study explores how such a world might function and what it would mean for our present conceptions of deterrence, for the place of the United States in the international order, and for international order itself.

Shoeboy in Pumpkin Land is a wonderfully surreal and Carrollesque opera for young people, brought to you by the wacky partnership of mad lyricist, Max Scratchmann, and round-the-bend composer, Michael Dyer. Dealing with the joint themes of alienation and acceptance in a darkly comic manner, this easy-to-stage one-act opera is the perfect vehicle for schools and/or youth theatre companies seeking to help children confront serious issues in a fun way. Jasper Jedd is an ordinary boy except for one little thing - he is born with a shoe for a head! And in this feast of devilish wit and roguish musical creativity he sets off on a journey through the dark forest of the fearsome Ginkle Snicks to find the mythical Pumpkin Land, where he hopes he'll finally fit in...(Duration: 35 minutes) The cover price of this libretto includes photocopying rights for one production.

On February 2nd of this year, Sam LaCara, an elementary school principle, was murdered. In honor of Sam, and as a way to give his wife and daughters something happy to read this Christmas, a few friends and family members put together a book of Christmas stories. We are selling the book both in paperback and as an e-book, with all proceeds going to the girls' college funds. Please consider purchasing a copy and help us give a special Christmas gift to a wonderful family in need of some extra holiday cheer.

Survival Jobs for Actors brings you a directory of companies that hire actors and artists for flexible work. For the first time, the secrets and essential information to successfully finding a Survival Job that is right for you are at your fingertips. Survival Jobs isn't only for actors, it's for singers, dancers, musicians, and artists, all looking to make some extra money to pay the rent while they follow their dreams.

Caught up in the bright lights of the modern world, it is easy to pretend that the old myths and legends have lost their hold over our hearts and imaginations. Sometimes, when we least expect it, the old archetypes return in terrifying new forms. Gods and Monsters is an anthology that explores these themes with fifteen new tales of the fantastic from some of the brightest new talent in fantasy and horror.

Through our dreams, we explore our greatest fears and desires. Some believe that we tap into a vast ocean of human consciousness and experience. Other believe that we live with one foot in the material world and one that is unknowable. Journey with us into the Dreamlands. Featuring stories by: Caitlin R. Kiernan, Christa Faust, Bev Vincent, Jane Gwaltney, James S. Dorr, Amy J. Benesch, Gary McMahon, Gill Ainsworth, Larisa Walk, Louise Bohmer, Lisa Mantchev, and AC Wise