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Quantitative methods are revolutionizing modern molecular and
cellular biology. Groundbreaking technical advances are fueling the
rapid expansion in our ability to observe, as seen in
multidisciplinary studies that integrate theory, computation,
experimental assays, and the control of microenvironments.
Integrating new experimental and theoretical methods, Quantitative
Biology: From Molecular to Cellular Systems gives both new and
established researchers a solid foundation for starting work in
this field. The book is organized into three sections: Fundamental
Concepts covers bold ideas that inspire novel approaches in modern
quantitative biology. It offers perspectives on evolutionary
dynamics, system design principles, chance and memory, and
information processing in biology. Methods describes recently
developed or improved techniques that are transforming biological
research. It covers experimental methods for studying
single-molecule biochemistry, small-angle scattering from
biomolecules, subcellular localization of proteins, and single-cell
behavior. It also describes theoretical methods for synthetic
biology and modeling random variations among cells. Molecular and
Cellular Systems focuses on specific biological systems where
modern quantitative biology methods are making an impact. It
incorporates case studies of biological systems for which new
concepts or methods are increasing our understanding. Examples
include protein kinase at the molecular level, the genetic switch
of phage lambda at the regulatory system level, and Escherichia
coli chemotaxis at the cellular level. In short, Quantitative
Biology presents practical tools for the observation, modeling,
design, and manipulation of biological systems from the molecular
to the cellular levels.
Quantitative methods are revolutionizing modern molecular and
cellular biology. Groundbreaking technical advances are fueling the
rapid expansion in our ability to observe, as seen in
multidisciplinary studies that integrate theory, computation,
experimental assays, and the control of microenvironments.
Integrating new experimental and theoretical methods, Quantitative
Biology: From Molecular to Cellular Systems gives both new and
established researchers a solid foundation for starting work in
this field. The book is organized into three sections: Fundamental
Concepts covers bold ideas that inspire novel approaches in modern
quantitative biology. It offers perspectives on evolutionary
dynamics, system design principles, chance and memory, and
information processing in biology. Methods describes recently
developed or improved techniques that are transforming biological
research. It covers experimental methods for studying
single-molecule biochemistry, small-angle scattering from
biomolecules, subcellular localization of proteins, and single-cell
behavior. It also describes theoretical methods for synthetic
biology and modeling random variations among cells. Molecular and
Cellular Systems focuses on specific biological systems where
modern quantitative biology methods are making an impact. It
incorporates case studies of biological systems for which new
concepts or methods are increasing our understanding. Examples
include protein kinase at the molecular level, the genetic switch
of phage lambda at the regulatory system level, and Escherichia
coli chemotaxis at the cellular level. In short, Quantitative
Biology presents practical tools for the observation, modeling,
design, and manipulation of biological systems from the molecular
to the cellular levels.
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