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Proteins interacting with diverse ligands - proteins, peptides or
DNA - are the basic principles underlying many biological
processes, such as antigen-antibody binding, signal transduction or
receptor binding.
The technique of oligopeptide synthesis on a cellulose membrane and
the subsequent binding assays allow the investigation of protein
interactions. A particular advantage of these peptide arrays (SPOT
- technology) is the high number of oligopeptide probes that can be
tested in parallel. Detailed protocols for peptide synthesis, and
the analysis of protein-protein, protein-DNA interactions as well
as epitope mapping are presented in this manual. It is ideally
suited not only for basic research laboratories but also for
diagnostic and therapeutic applications since many diseases are
related to dysfunctions in protein recognition and binding.
Precision Medicine and Artificial Intelligence: The Perfect Fit for
Autoimmunity covers background on artificial intelligence (AI), its
link to precision medicine (PM), and examples of AI in healthcare,
especially autoimmunity. The book highlights future perspectives
and potential directions as AI has gained significant attention
during the past decade. Autoimmune diseases are complex and
heterogeneous conditions, but exciting new developments and
implementation tactics surrounding automated systems have enabled
the generation of large datasets, making autoimmunity an ideal
target for AI and precision medicine. More and more diagnostic
products utilize AI, which is also starting to be supported by
regulatory agencies such as the Food and Drug Administration (FDA).
Knowledge generation by leveraging large datasets including
demographic, environmental, clinical and biomarker data has the
potential to not only impact the diagnosis of patients, but also
disease prediction, prognosis and treatment options.
Proteins interacting with diverse ligands - proteins, peptides or DNA - are the basic principles underlying many biological processes, such as antigen-antibody binding, signal transduction or receptor binding.The technique of oligopeptide synthesis on a cellulose membrane and the subsequent binding assays allow the investigation of protein interactions. A particular advantage of these peptide arrays (SPOT - technology) is the high number of oligopeptide probes that can be tested in parallel. Detailed protocols for peptide synthesis, and the analysis of protein-protein, protein-DNA interactions as well as epitope mapping are presented in this manual. It is ideally suited not only for basic research laboratories but also for diagnostic and therapeutic applications since many diseases are related to dysfunctions in protein recognition and binding.
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