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Ghrelin, the endogenous ligand for the growth hormone secretagogue
(GHS) receptor, is critical in the control of food intake and
energy balance. The ghrelin receptors are now known to have
important physiological properties as modulators of growth hormone
release, appetite, glucose homeostasis, metabolism, immune
function, neurotransmitter activity, cognitive function and
neurodegeneration. Bringing all of this information together in the
first comprehensive text on the topic, Ghrelin in Health and
Disease provides a state-of-the-art synthesis of the latest work in
this area for physicians and physician-scientists. This volume
addresses the unique property of ghrelin as a modulator of
function. Such a property provides potential utility for safe
intervention in a wide variety of disease states. Indeed as we
learn more about the basic physiology of ghrelin, the potential for
treating new disease targets emerge requiring validation in the
clinic. Each chapter in this volume is authored by a leading
investigator in the field. The introductory chapter sets the
background for the book and provides a superb overview of the
relevance of ghrelin to physiology, describing how the discovery of
ghrelin has prompted us to completely rethink traditional
physiology. The authors conclude their chapters by critically
addressing the future translational aspects of ghrelin biology and
outlining what key basic research and clinical questions remain to
be addressed. An invaluable resource, Ghrelin in Health and Disease
distinguishes itself as the first comprehensive title covering all
of the molecular and clinical issues relating to ghrelin and
advancing our clinical understanding of obesity, growth, and
reproductive pathogenesis.
Ghrelin, the endogenous ligand for the growth hormone secretagogue
(GHS) receptor, is critical in the control of food intake and
energy balance. The ghrelin receptors are now known to have
important physiological properties as modulators of growth hormone
release, appetite, glucose homeostasis, metabolism, immune
function, neurotransmitter activity, cognitive function and
neurodegeneration. Bringing all of this information together in the
first comprehensive text on the topic, Ghrelin in Health and
Disease provides a state-of-the-art synthesis of the latest work in
this area for physicians and physician-scientists. This volume
addresses the unique property of ghrelin as a modulator of
function. Such a property provides potential utility for safe
intervention in a wide variety of disease states. Indeed as we
learn more about the basic physiology of ghrelin, the potential for
treating new disease targets emerge requiring validation in the
clinic. Each chapter in this volume is authored by a leading
investigator in the field. The introductory chapter sets the
background for the book and provides a superb overview of the
relevance of ghrelin to physiology, describing how the discovery of
ghrelin has prompted us to completely rethink traditional
physiology. The authors conclude their chapters by critically
addressing the future translational aspects of ghrelin biology and
outlining what key basic research and clinical questions remain to
be addressed. An invaluable resource, Ghrelin in Health and Disease
distinguishes itself as the first comprehensive title covering all
of the molecular and clinical issues relating to ghrelin and
advancing our clinical understanding of obesity, growth, and
reproductive pathogenesis.
In a state-of-the-art synthesis of basic science and clinical
practice, Roy Smith and a distinguished panel of researchers and
clinicians review GH regulation and its action at the molecular
level, and describe the basis for GH deficiency and the use of GH
as therapy in a variety of clinical situations. The clinical
presentation moves beyond the treatment of GH-deficient children to
include the genetics of GH-deficiency, GH-deficiency in adults,
osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH
in clinical studies. Timely and innovative, Human Growth Hormone:
Research and Clinical Practice will benefit both basic and clinical
researchers, as well as those clinical endocrinologists who want to
use growth hormone not only in treating children, but also in
treating adult disorders, including those associated with metabolic
disease.
For many years now, our understanding of the somatotrophic and
reproduc tive axes has evolved essentially independently, both
fields of study reaching a highly advanced, although far from
complete, level of under standing. Along the way, however, it
became apparent that in some circumstances the reproductive and
somatotrophic axes may be inter dependent. Inklings to this effect
were at times feeble and at other times more convincing. Among
those inklings are the clinical recognition by pediatric
endocrinologists of the apparent association between isolated GH
deficiency and delayed puberty, as well as of the apparent
permissive, pUberty-promoting property of GH. Equally important is
a body of experi mental studies establishing the ovary of multiple
species as a site of GH reception and action. Arguing against an
essential role for GH in the reproductive process is the
observation that individuals who have GH resistance of the Laron
variety are fertile arid that isolated GH deficiency does not
constitute an absolute barrier to the attainment of sexual
maturation and fertility. The intraovarian insulin-like growth
factor (IGF) hypothesis proposes that IGFs may serve as amplifiers
of gonadotropin action. Although the dependence of intraovarian
IGFs on systemic GH action has never been unequivocally
demonstrated, that leap of faith has often been made. The
intraovarian IGF hypothesis serves as the rationale for the
adjunctive use of GH in the induction of ovulation."
In a state-of-the-art synthesis of basic science and clinical
practice, Roy Smith and a distinguished panel of researchers and
clinicians review GH regulation and its action at the molecular
level, and describe the basis for GH deficiency and the use of GH
as therapy in a variety of clinical situations. The clinical
presentation moves beyond the treatment of GH-deficient children to
include the genetics of GH-deficiency, GH-deficiency in adults,
osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH
in clinical studies. Timely and innovative, Human Growth Hormone:
Research and Clinical Practice will benefit both basic and clinical
researchers, as well as those clinical endocrinologists who want to
use growth hormone not only in treating children, but also in
treating adult disorders, including those associated with metabolic
disease.
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