This issue of Neurologic Clinics, guest edited by Dr. José Biller, is devoted to Therapy in Neurology. This issue is one of four selected each year by the series Consulting Editor, Dr. Randolph W. Evan. Articles in this issue include: Update on CGRP Antagonism in the Treatment of Migraine, Advances in the Treatment of Multiple Sclerosis, Advances in the Treatment of Neuromyelitis Optica Spectrum Disorder, Advances and ongoing controversies in PFO closure and cryptogenic stroke, Advances in neuromodulation/neurostimulation in Neurology, Advances in the treatment of muscular dystrophies and motor neuron disorders, Advances in the management of small fiber neuropathies, Update in the treatment of Idiopathic Intracranial Hypertension, What is new in neuro-oncology?, Advances in the surgical management of epilepsy, Treatment of Viral Encephalitis, An update on Botulinum toxin in neurology, Cannabinoids in neurological illnesses, and Pitfalls in Transitioning Neurological Care of the Developmentally Disabled from Pediatric to Adult Providers. Contains 13 practice-oriented topics including medical aid in dying; legal and ethical issues in the neurology of reproductive health; brain death: ethical and legal challenges; organ donation and controlled determination of death by circulatory criteria; ethics and legal issues regarding global neurology; and more.  Provides in-depth clinical reviews of medicolegal issues in neurology, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. 

For decades, US foreign policy in the Middle East has been on autopilot: Seek Arab-Israeli peace, fight terrorism, and urge regimes to respect human rights. Every US administration puts its own spin on these initiatives, but none has successfully resolved the region’s fundamental problems. In Seven Pillars: What Really Causes Instability in the Middle East? a bipartisan group of leading experts representing several academic and policy disciplines unravel the core causes of instability in the Middle East and North Africa. Why have some countries been immune to the Arab Spring? Which governments enjoy the most legitimacy and why? With more than half the region under 30 years of age, why does education and innovation lag? How do resource economies, crony capitalism, and inequality drive conflict? Are ethnic and sectarian fault lines the key factor, or are these more products of political and economic instability? And what are the wellsprings of extremism that threaten not only the United States but, more profoundly, the people of the region? The answers to these questions should help policymakers and students of the region understand the Middle East on its own terms, rather than just through a partisan or diplomatic lens. Understanding the pillars of instability in the region can allow the United States and its allies to rethink their own priorities, adjust policy, recalibrate their programs, and finally begin to chip away at core challenges facing the Middle East. Contributors: Thanassis Cambanis Michael A. Fahy Florence Gaub Danielle Pletka Bilal Wahab A. Kadir Yildirim

For decades, US foreign policy in the Middle East has been on autopilot: Seek Arab-Israeli peace, fight terrorism, and urge regimes to respect human rights. Every US administration puts its own spin on these initiatives, but none has successfully resolved the region’s fundamental problems. In Seven Pillars: What Really Causes Instability in the Middle East? a bipartisan group of leading experts representing several academic and policy disciplines unravel the core causes of instability in the Middle East and North Africa. Why have some countries been immune to the Arab Spring? Which governments enjoy the most legitimacy and why? With more than half the region under 30 years of age, why does education and innovation lag? How do resource economies, crony capitalism, and inequality drive conflict? Are ethnic and sectarian fault lines the key factor, or are these more products of political and economic instability? And what are the wellsprings of extremism that threaten not only the United States but, more profoundly, the people of the region? The answers to these questions should help policymakers and students of the region understand the Middle East on its own terms, rather than just through a partisan or diplomatic lens. Understanding the pillars of instability in the region can allow the United States and its allies to rethink their own priorities, adjust policy, recalibrate their programs, and finally begin to chip away at core challenges facing the Middle East. Contributors: Thanassis Cambanis Michael A. Fahy Florence Gaub Danielle Pletka Bilal Wahab A. Kadir Yildirim

In 1986, Bar/None Records released They Might Be Giants first album. Now to commemorate 20 years of influential music, we are issuing a very special tribute to Brooklyn's legendary alternative rockers. Die-hard fans can expect appearances from some pretty heavy hitters and some good friends of TMBG. Artists appearing on the album include Frank Black, The Long Winters, OK Go, indie-rock darlings the Wrens, as well as Bar/None artists Hotel Lights and Jason Trachtenburg. There's truly something for everyone from the casual fan to the obsessive completist.