Since the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflammatory drugs (NSAIDs), much research has gone into the development of methods to study the biological functions of COX-1 and COX-2. In Cyclooxygenases: Methods and Protocols, experts and pioneers in the field present the most up-to-date in vitro and in vivo techniques routinely used in COX research. The volume delves into essential topics such as the purification, cloning, and expression of COX enzymes as well as in vitro assays aimed at determining the inhibitory potency of drugs on COX-1 and COX-2 activities, with chapters describing protocols used for the extraction and measurement of the prostanoids. This volume also describes in vivo disease models used to study the roles of COX-1 and COX-2 in gastrointestinal injury, inflammation, and pain. As a book in the highly successful Methods in Molecular Biology (TM) series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cyclooxygenases: Methods and Protocols serves as an indispensable tool for all scientists seeking the treatment of inflammation, pain, fever, and other harmful conditions.

Fascinating, engaging and extremely visual, FOUNDATIONS OF ASTRONOMY, 14th Edition, is renowned for its current coverage, reader-friendly presentation and detailed--yet clear--explanations. The authors' goals are to help you use Astronomy to understand science, and use science to answer two fundamental questions: What are we? And how do we know? Available with WebAssign, the powerful digital solution that enriches the teaching and learning experience. Complete with practice opportunities, a wealth of supplemental resources and immediate feedback, you'll be set up to succeed.

Since the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflammatory drugs (NSAIDs), much research has gone into the development of methods to study the biological functions of COX-1 and COX-2. In Cyclooxygenases: Methods and Protocols, experts and pioneers in the field present the most up-to-date in vitro and in vivo techniques routinely used in COX research. The volume delves into essential topics such as the purification, cloning, and expression of COX enzymes as well as in vitro assays aimed at determining the inhibitory potency of drugs on COX-1 and COX-2 activities, with chapters describing protocols used for the extraction and measurement of the prostanoids. This volume also describes in vivo disease models used to study the roles of COX-1 and COX-2 in gastrointestinal injury, inflammation, and pain. As a book in the highly successful Methods in Molecular Biology (TM) series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cyclooxygenases: Methods and Protocols serves as an indispensable tool for all scientists seeking the treatment of inflammation, pain, fever, and other harmful conditions.

FOUNDATIONS OF ASTRONOMY, 11e, INTERNATIONAL EDITION brings science to life. With this newly revised Eleventh Edition of FOUNDATIONS OF ASTRONOMY, INTERNATIONAL EDITION, best-selling authors Mike Seeds and Dana Backman strive to help students use astronomy to understand science--and use science to understand what we are. Fascinating, engaging, and extremely visual, this text emphasizes the scientific method throughout as it guides students to answer two fundamental questions: What are we? And how do we know? In discussing the interplay between evidence and hypothesis, the authors provide not only fact but also a conceptual framework for understanding the logic of science. The Eleventh Edition addresses the newest developments and latest discoveries in the exciting study of astronomy, including information to emphasize observations over the entire electromagnetic spectrum; new data on star formation and stellar structure; new insight on global warming and ozone depletion; updated information on the Kuiper belt and dwarf planets; and more. Whether you choose to assign homework in an online environment, give your students access to an affordable and interactive online text, or do both, the new FOUNDATIONS OF ASTRONOMY, INTERNATIONAL EDITION Online Version is the ideal solution for your course needs, giving your students Web-based access to a digital version of the text. In addition, the new online Enhanced WebAssign (R) homework management system enables you to easily assign and manage homework online.

Fascinating, engaging and extremely visual, STARS AND GALAXIES, 10th Edition, is renowned for its current coverage, reader-friendly presentation and detailed--yet clear--explanations. The authors' goals are to help you use Astronomy to understand science, and use science to answer two fundamental questions: What are we? And how do we know? Available with WebAssign, the powerful digital solution that enriches the teaching and learning experience. It includes Virtual Astronomy Labs 3.0--a set of 20 interactive activities that combine analysis of real astronomical data with robust simulations--providing a true online laboratory experience for your Introductory Astronomy course.

Fascinating, engaging, and extremely visual, FOUNDATIONS OF ASTRONOMY, Thirteenth Edition, is renowned for its current coverage, reader-friendly presentation, and detailed, yet clear explanations. The authors' goals are to help you use astronomy to understand science--and use science to answer two fundamental questions: What are we? And how do we know?

With their best-selling astronomy textbook, HORIZONS, International Edition authors Mike Seeds and Dana Backman help you understand your place in the universe--not just your location in space but your role in the unfolding history of the physical universe. To achieve this goal, they focuses on two central questions: "What Are We?" which highlights your place as a planet dweller in an evolving universe, guiding you to better understand where we came from and how we formed; and "How Do We Know?" which provides insights into how the process of science can teach us more about what we are.

Fascinating, engaging, and extremely visual, FOUNDATIONS OF ASTRONOMY, Enhanced Thirteenth Edition, is renowned for its current coverage, reader-friendly presentation, and detailed, yet clear explanations. The authors' goals are to help you use astronomy to understand science—and use science to answer two fundamental questions: What are we? And how do we know?

Focusing on two central questions -- "What are we?" and "How Do We Know?" -- HORIZONS: EXPLORING THE UNIVERSE, 14th Edition, helps you understand our place in the universe and how scientists work. Chapter-opening "Guideposts" and a conversational writing style make the content accessible and help you acquire an understanding of the universe (rather than just memorize basic facts); and online resources let you study where and when you want, to best meet your individual learning style.

Fascinating, engaging and extremely visual,THE SOLAR SYSTEM, 10th Edition, is renowned for its current coverage, reader-friendly presentation and detailed--yet clear--explanations. The authors' goals are to help you use Astronomy to understand science, and use science to answer two fundamental questions: What are we? And how do we know? Available with WebAssign, the powerful digital solution that enriches the teaching and learning experience. It includes Virtual Astronomy Labs 3.0--a set of 20 interactive activities that combine analysis of real astronomical data with robust simulations--providing a true online laboratory experience for your Introductory Astronomy course.