With their best-selling astronomy textbook, HORIZONS, International Edition authors Mike Seeds and Dana Backman help you understand your place in the universe--not just your location in space but your role in the unfolding history of the physical universe. To achieve this goal, they focuses on two central questions: "What Are We?" which highlights your place as a planet dweller in an evolving universe, guiding you to better understand where we came from and how we formed; and "How Do We Know?" which provides insights into how the process of science can teach us more about what we are.

Since the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflammatory drugs (NSAIDs), much research has gone into the development of methods to study the biological functions of COX-1 and COX-2. In Cyclooxygenases: Methods and Protocols, experts and pioneers in the field present the most up-to-date in vitro and in vivo techniques routinely used in COX research. The volume delves into essential topics such as the purification, cloning, and expression of COX enzymes as well as in vitro assays aimed at determining the inhibitory potency of drugs on COX-1 and COX-2 activities, with chapters describing protocols used for the extraction and measurement of the prostanoids. This volume also describes in vivo disease models used to study the roles of COX-1 and COX-2 in gastrointestinal injury, inflammation, and pain. As a book in the highly successful Methods in Molecular Biology (TM) series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cyclooxygenases: Methods and Protocols serves as an indispensable tool for all scientists seeking the treatment of inflammation, pain, fever, and other harmful conditions.

Fascinating, engaging and extremely visual, FOUNDATIONS OF ASTRONOMY, 14th Edition, is renowned for its current coverage, reader-friendly presentation and detailed--yet clear--explanations. The authors' goals are to help you use Astronomy to understand science, and use science to answer two fundamental questions: What are we? And how do we know? Available with WebAssign, the powerful digital solution that enriches the teaching and learning experience. Complete with practice opportunities, a wealth of supplemental resources and immediate feedback, you'll be set up to succeed.

Since the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflammatory drugs (NSAIDs), much research has gone into the development of methods to study the biological functions of COX-1 and COX-2. In Cyclooxygenases: Methods and Protocols, experts and pioneers in the field present the most up-to-date in vitro and in vivo techniques routinely used in COX research. The volume delves into essential topics such as the purification, cloning, and expression of COX enzymes as well as in vitro assays aimed at determining the inhibitory potency of drugs on COX-1 and COX-2 activities, with chapters describing protocols used for the extraction and measurement of the prostanoids. This volume also describes in vivo disease models used to study the roles of COX-1 and COX-2 in gastrointestinal injury, inflammation, and pain. As a book in the highly successful Methods in Molecular Biology (TM) series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cyclooxygenases: Methods and Protocols serves as an indispensable tool for all scientists seeking the treatment of inflammation, pain, fever, and other harmful conditions.

Focusing on two central questions -- "What are we?" and "How Do We Know?" -- HORIZONS: EXPLORING THE UNIVERSE, 14th Edition, helps you understand our place in the universe and how scientists work. Chapter-opening "Guideposts" and a conversational writing style make the content accessible and help you acquire an understanding of the universe (rather than just memorize basic facts); and online resources let you study where and when you want, to best meet your individual learning style.

Fascinating, engaging and extremely visual, STARS AND GALAXIES, 10th Edition, is renowned for its current coverage, reader-friendly presentation and detailed--yet clear--explanations. The authors' goals are to help you use Astronomy to understand science, and use science to answer two fundamental questions: What are we? And how do we know? Available with WebAssign, the powerful digital solution that enriches the teaching and learning experience. It includes Virtual Astronomy Labs 3.0--a set of 20 interactive activities that combine analysis of real astronomical data with robust simulations--providing a true online laboratory experience for your Introductory Astronomy course.

Michael Seed should have had what every child deserves: love, care and attention, and the chance to be just what he was - an innocent young boy. Instead, Michael's formative years were filled with unspeakable neglect, misery and abuse from an alcoholic father who robbed him of his childhood and drove his mother to suicide. One horrific night, Michael realized that the situation was escalating as his father began the sexual abuse that would continue for years. School offered no reprieve as Michael encountered terrible bullying and a teacher who repeatedly violated him. It seemed he was destined for a life of inescapable misery. Despite everything, Michael was ultimately saved by his own will to live and by the books that inspired him to move on and seek a better life. After years of silence, Michael is ready to tell his story, a story that, though shockingly painful, is a testament to his remarkable ability to triumph in the face of the most appalling circumstances and to escape the horrors of his past.

Father Michael Seed has been at the privileged center of events for a quarter of a century, and has played a uniquely influential role. In this explosive memoir Britain's "priest to the stars" covers his encounters with some of the most prominent political and public figures of a generation, and gives a rare and fascinating glimpse of behind-the-scenes events in the corridors of power. His remarkable disclosures of life at the top, in parliament, palace, and church, are revealed through a series of hilarious anecdotes that will have readres laughing out loud. For years he secretly gave Mass to the Blairs in Dowing Street, initially slipping in through a rear, ground floor window, before it was leaked to the press in 2006. His has been a turbulent ride through life, denounced and envied by those who dislike his champagne style of Catholicism, loved by those who declare him a saint, and so admired by the "Times" that it demanded he be instantly made a bishop. His friendship with people like best chum Ann Widdecombe, Alan Clark, the Dutchess of Argyll, Lord Longford, George Carman QC, John Paul Getty, the Duke of Norfolk, a host of royals, and half a dozen prime ministers, has left little room for dullness. His insights into life in Westminster Cathedral and with Cardinal Basil Hume make all religion-based television sitcoms seem deadly boring by comparison with the real thing.

With this revised edition of THE SOLAR SYSTEM, author Mike Seeds' goal is to help you use astronomy to understand science -- and use science to understand what we are. Fascinating and engaging, this text will help you answer two fundamental questions: What are we? How do we know? Crafting a story about astronomy, Seeds shows you how to ask questions to gradually puzzle out the beautiful secrets of the physical world and our place in it. This edition addresses the newest developments and latest discoveries in the exciting study of astronomy, including new data on Jupiter's ring system; new observations of the shapes of stars; new evidence of dark energy, quasars, and galaxy collisions; and a look inside supernova explosions.

Fascinating, engaging, and extremely visual, FOUNDATIONS OF ASTRONOMY, Thirteenth Edition, is renowned for its current coverage, reader-friendly presentation, and detailed, yet clear explanations. The authors' goals are to help you use astronomy to understand science--and use science to answer two fundamental questions: What are we? And how do we know?

Fascinating, engaging, and extremely visual, FOUNDATIONS OF ASTRONOMY, Enhanced Thirteenth Edition, is renowned for its current coverage, reader-friendly presentation, and detailed, yet clear explanations. The authors' goals are to help you use astronomy to understand science—and use science to answer two fundamental questions: What are we? And how do we know?

Fascinating, engaging and extremely visual,THE SOLAR SYSTEM, 10th Edition, is renowned for its current coverage, reader-friendly presentation and detailed--yet clear--explanations. The authors' goals are to help you use Astronomy to understand science, and use science to answer two fundamental questions: What are we? And how do we know? Available with WebAssign, the powerful digital solution that enriches the teaching and learning experience. It includes Virtual Astronomy Labs 3.0--a set of 20 interactive activities that combine analysis of real astronomical data with robust simulations--providing a true online laboratory experience for your Introductory Astronomy course.