Since the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflammatory drugs (NSAIDs), much research has gone into the development of methods to study the biological functions of COX-1 and COX-2. In Cyclooxygenases: Methods and Protocols, experts and pioneers in the field present the most up-to-date in vitro and in vivo techniques routinely used in COX research. The volume delves into essential topics such as the purification, cloning, and expression of COX enzymes as well as in vitro assays aimed at determining the inhibitory potency of drugs on COX-1 and COX-2 activities, with chapters describing protocols used for the extraction and measurement of the prostanoids. This volume also describes in vivo disease models used to study the roles of COX-1 and COX-2 in gastrointestinal injury, inflammation, and pain. As a book in the highly successful Methods in Molecular Biology (TM) series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cyclooxygenases: Methods and Protocols serves as an indispensable tool for all scientists seeking the treatment of inflammation, pain, fever, and other harmful conditions.

Fascinating, engaging and extremely visual,THE SOLAR SYSTEM, 10th Edition, is renowned for its current coverage, reader-friendly presentation and detailed--yet clear--explanations. The authors' goals are to help you use Astronomy to understand science, and use science to answer two fundamental questions: What are we? And how do we know? Available with WebAssign, the powerful digital solution that enriches the teaching and learning experience. It includes Virtual Astronomy Labs 3.0--a set of 20 interactive activities that combine analysis of real astronomical data with robust simulations--providing a true online laboratory experience for your Introductory Astronomy course.

Fascinating, engaging and extremely visual, FOUNDATIONS OF ASTRONOMY, 14th Edition, is renowned for its current coverage, reader-friendly presentation and detailed--yet clear--explanations. The authors' goals are to help you use Astronomy to understand science, and use science to answer two fundamental questions: What are we? And how do we know? Available with WebAssign, the powerful digital solution that enriches the teaching and learning experience. Complete with practice opportunities, a wealth of supplemental resources and immediate feedback, you'll be set up to succeed.

Since the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflammatory drugs (NSAIDs), much research has gone into the development of methods to study the biological functions of COX-1 and COX-2. In Cyclooxygenases: Methods and Protocols, experts and pioneers in the field present the most up-to-date in vitro and in vivo techniques routinely used in COX research. The volume delves into essential topics such as the purification, cloning, and expression of COX enzymes as well as in vitro assays aimed at determining the inhibitory potency of drugs on COX-1 and COX-2 activities, with chapters describing protocols used for the extraction and measurement of the prostanoids. This volume also describes in vivo disease models used to study the roles of COX-1 and COX-2 in gastrointestinal injury, inflammation, and pain. As a book in the highly successful Methods in Molecular Biology (TM) series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cyclooxygenases: Methods and Protocols serves as an indispensable tool for all scientists seeking the treatment of inflammation, pain, fever, and other harmful conditions.

Fascinating, engaging and extremely visual, STARS AND GALAXIES, 10th Edition, is renowned for its current coverage, reader-friendly presentation and detailed--yet clear--explanations. The authors' goals are to help you use Astronomy to understand science, and use science to answer two fundamental questions: What are we? And how do we know? Available with WebAssign, the powerful digital solution that enriches the teaching and learning experience. It includes Virtual Astronomy Labs 3.0--a set of 20 interactive activities that combine analysis of real astronomical data with robust simulations--providing a true online laboratory experience for your Introductory Astronomy course.

Focusing on two central questions -- "What are we?" and "How Do We Know?" -- HORIZONS: EXPLORING THE UNIVERSE, 14th Edition, helps you understand our place in the universe and how scientists work. Chapter-opening "Guideposts" and a conversational writing style make the content accessible and help you acquire an understanding of the universe (rather than just memorize basic facts); and online resources let you study where and when you want, to best meet your individual learning style.

With their best-selling astronomy textbook, HORIZONS, International Edition authors Mike Seeds and Dana Backman help you understand your place in the universe--not just your location in space but your role in the unfolding history of the physical universe. To achieve this goal, they focuses on two central questions: "What Are We?" which highlights your place as a planet dweller in an evolving universe, guiding you to better understand where we came from and how we formed; and "How Do We Know?" which provides insights into how the process of science can teach us more about what we are.

Fascinating, engaging, and extremely visual, FOUNDATIONS OF ASTRONOMY, Thirteenth Edition, is renowned for its current coverage, reader-friendly presentation, and detailed, yet clear explanations. The authors' goals are to help you use astronomy to understand science--and use science to answer two fundamental questions: What are we? And how do we know?

Fascinating, engaging, and extremely visual, FOUNDATIONS OF ASTRONOMY, Enhanced Thirteenth Edition, is renowned for its current coverage, reader-friendly presentation, and detailed, yet clear explanations. The authors' goals are to help you use astronomy to understand science—and use science to answer two fundamental questions: What are we? And how do we know?